2008
DOI: 10.1038/sj.cdd.4402312
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Abstract: Apoptosis consists of highly regulated pathways involving post-translational modifications and cleavage of proteins leading to sequential inactivation of the main cellular processes. Here, we focused on the apoptotic processing of one of the essential components of the mRNA splicing machinery, the U1-70K snRNP protein. We found that at an early stage of apoptosis, before the cleavage of the C-terminal part of the protein by caspase-3, the basal phosphorylation of the Ser140 residue located within the RNA recog… Show more

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Cited by 36 publications
(42 citation statements)
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“…Apoptotic cell bodies also have been termed late apoptotic or secondary necrotic cells. During apoptosis, various modifications of autoantigens (e.g., chromatin) may take place, including cleavage by proteinases, caspases, and/or endonucleases and specific posttranslational modifications (6,(11)(12)(13)(14)(15). These findings suggest that apoptotic blebs are a source of (modified) autoantigens and that they may play a key role in the development of the antichromatin response in SLE.…”
mentioning
confidence: 99%
“…Apoptotic cell bodies also have been termed late apoptotic or secondary necrotic cells. During apoptosis, various modifications of autoantigens (e.g., chromatin) may take place, including cleavage by proteinases, caspases, and/or endonucleases and specific posttranslational modifications (6,(11)(12)(13)(14)(15). These findings suggest that apoptotic blebs are a source of (modified) autoantigens and that they may play a key role in the development of the antichromatin response in SLE.…”
mentioning
confidence: 99%
“…HERDS contain many RNA-associated autoantigens, such as the U1-70K protein ( Fig. 1 and ref [20]) and the Sm antigen [54], which are not degraded since they are still detectable by antibody probes. In addition, HERDS contain still detectable RNA [56].…”
Section: Relocation Of Nuclear Proteinsmentioning
confidence: 99%
“…The apoptotic cell has been proposed as the source of nuclear autoantigens targeted during lupus, since (i) nuclear autoantigens were identified in apoptotic surface blebs [8]; (ii) mice deficient in molecules involved in the removal of apoptotic cells develop lupus-like autoimmunity [9,10]; (iii) apoptotic cells, especially in combination with dendritic cells (DCs) are able to activate autoreactive T cells and induce an anti-nuclear immune response in mice [11][12][13]; and (iv) autoantibodies from lupus patients and mice preferably recognize modified proteins from apoptotic cells [14][15][16][17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…This U1-snRNP complex is one component of the spliceosome (1,2). A subset of patients with SLE, and all patients with mixed connective tissue disease (MCTD), develop autoantibodies against U1-snRNP, and U1-70 in particular (1,(3)(4)(5). Anti-snRNP autoantibodies are detectable before overt disease in SLE in what is termed a "pathogenic autoimmunity" phase (6).…”
mentioning
confidence: 99%