Biochemical Pharmacology volume 76, issue 11, P1612-1619 2008 DOI: 10.1016/j.bcp.2008.08.013 View full text
Amir M. Hossini, Jürgen Eberle

Abstract: Bcl-2 proteins, characterized by up to four Bcl-2 homology domains (BH1-BH4), are critical regulators of the mitochondrial proapoptotic pathway. Three major subgroups have been described, namely antiapoptotic proteins, proapoptotic multidomain and BH3-only proteins. These are basic for present models explaining the regulation of the mitochondrial outer membrane permeability. However, several Bcl-2 proteins have been described that do not fit into these models, due to their atypical domain structure or due to t…

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