Apoptosis in human hepatoma HepG2 cells induced by corn peptides and its anti-tumor efficacy in H22 tumor bearing mice

Li, Jiangtao; Zhang, Jiu‐liang; He, Hui; Ma, Zhili; Nie, Zhi-Kui; Wang, Zhenzhen; Xu, Xiao-Gen

doi:10.1016/j.fct.2012.09.038

Cited by 79 publications

(50 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More attention has been paid to the anticancer activity of CPs, and several anticancer mechanisms have been elucidated (Li et al., ). For instance, Yamaguchi, Takeuchi, and Ebihara () have reported that peptides from CGM play an important role in controlling the development of mammary tumors in female rats.…”

Section: Biological Activities and Corresponding Mechanisms Of Bioactmentioning

confidence: 99%

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Zhu

Hou

2018

Comp Rev Food Sci Food Safe

Self Cite

View full text Add to dashboard Cite

Bioactive peptides are specific peptide fragments that positively exert various functional and biological activities and ultimately influence health. Corn protein are potential precursor proteins for bioactive peptides. This review encompasses the studies reported to date on the production, isolation, purification, and characterization technologies of bioactive corn peptides (CPs), with particular attention being devoted to these peptides’ different health effects, including antioxidant, antihypertensive, hepatoprotective, alcohol‐metabolism‐facilitating, anti‐inflammatory, anticancer, antimicrobial, and dipeptidyl peptidase IV (DPP‐IV) inhibitory activities. The review also describes studies examining the potential mechanisms believed to be involved in these bioactivities, and the possible absorption and transport pathways of CPs are summarized.

show abstract

Section: Biological Activities and Corresponding Mechanisms Of Bioactmentioning

confidence: 99%

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Zhu

Hou

2018

Comp Rev Food Sci Food Safe

Self Cite

View full text Add to dashboard Cite

show abstract

“…But on the other hand, CGM contains a high proportion of hydrophobic amino acids (leucine, alanine, phenylalanine, etc.) [4], which makes it become a potential source for peptides with biological activities such as antioxidant activity [5], antihypertensive effect [6], facilitating alcohol effect [7], and antitumor efficacy [8], while the poor solubility of corn protein and the special structure have created barrier for enzymes to cleave the protein, which seriously limited the functional peptides' release and reduced the corn protein's bioavailability. Therefore, developing a more efficient technique to overcome these problems is of great interest to food scientists all over the world.…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Frequency Ultrasonic-Assisted Enzymolysis on the Physicochemical and Antioxidant Properties of Corn Protein Hydrolysates

Liang

Ren

et al. 2017

Journal of Food Quality

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of low-frequency ultrasound on the enzymolysis of corn protein. A L 9 (3 4 ) orthogonal design was used to optimize ultrasound pretreatment conditions. Degree hydrolysis (DH), conversion rate of protein (CR), and DPPH IC 50 were selected as analytical indicators. Under the optimal ultrasound conditions (5 W/L power, 2 s/2 s on/off time, 50 ∘ C temperature, and 25 min time), the DH, CR, and radical (DPPH • ,• OH) scavenging capacities were significantly increased. Molecular weight distribution and amino acid profile analysis showed that ultrasound pretreatment enhanced the formation of short-chain peptides with molecular weight of 200-3000 Da, especially the peptides containing hydrophobic amino acids. Moreover, 40 potential antioxidant peptides were purified by C18 semipreparative column and identified by UPLC-ESI-MS. The results suggest that the optimal ultrasonic-assisted enzymolysis technology could be useful for preparation of antioxidant peptides from corn.

show abstract

“…HepG2 cells showed an increase in apoptotic activity when they were exposed to maize peptides obtained by enzymatic hydrolysis of protein extracted from corn gluten meal (Li et al, 2013). In that study, maize peptides were also evaluated in H22-tumor bearing mice.…”

Section: Health Effects Of Maize Peptidesmentioning

confidence: 99%

Anti-Cancer Activity of Maize Bioactive Peptides

et al. 2017

View full text Add to dashboard Cite

Cancer is one of the main chronic degenerative diseases worldwide. In recent years, consumption of whole-grain cereals and their derivative food products has been associated with a reduced risk of various types of cancer. The main biomolecules in cereals include proteins, peptides, and amino acids, all of which are present in different quantities within the grain. Some of these peptides possess nutraceutical properties and exert biological effects that promote health and prevent cancer. In this review, we report the current status and advances in knowledge regarding the bioactive properties of maize peptides, such as antioxidant, antihypertensive, hepatoprotective, and anti-tumor activities. We also highlight the potential biological mechanisms through which maize bioactive peptides exert anti-cancer activity. Finally, we analyze and emphasize the potential applications of maize peptides.

show abstract

Apoptosis in human hepatoma HepG2 cells induced by corn peptides and its anti-tumor efficacy in H22 tumor bearing mice

Cited by 79 publications

References 27 publications

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

Effect of Low-Frequency Ultrasonic-Assisted Enzymolysis on the Physicochemical and Antioxidant Properties of Corn Protein Hydrolysates

Anti-Cancer Activity of Maize Bioactive Peptides

Contact Info

Product

Resources

About