Biochemical Pharmacology volume 77, issue 7, P1139-1150 2009 DOI: 10.1016/j.bcp.2008.12.016 View full text
Xu Di, Robert P. Shiu, Irene F. Newsham, David A. Gewirtz

Abstract: Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1. Suppression of apoptosis in MDA-MB231 and MCF-7/E6 cells treated with Adriamycin using the broad spectrum caspase inhibitor, zvad-Fmk, results in substantial induction of autop…

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