volume 8, issue 4, P603-619 2016
DOI: 10.18632/aging.100934
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Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci, Alessia Garufi, Gabriella D'Orazi

Abstract: Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged cells, such as those resulting from DNA damage or during development. Apoptosis can be triggered by signals from within the cell, such as genotoxic stress, or by extrinsic signals, such as the binding of ligands to cell surface death receptors. Deregulation in apoptotic cell death machinery is an hallmark of cancer. Apoptosis alteration is responsible not only for tumor development and progression but also…

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