Abstract:In the treatment of CNS neoplasms, radiation therapy to high biologically effective doses is performed in both fractionated and single fraction schemes. Inevitably, normal CNS tissues are irradiated, leading to both acute and late toxicities, and demanding greater insight into normal tissue effects and development of innovative strategies for radioprotection and mitigation. For this purpose, the cerebral organoid, which recapitulates many cell types and complex architectures of the human brain, is proposed as … Show more
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