Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Yumuşak, Nihat; Sadic, Murat; Yücel, Gözde; Atilgan, Hasan Ikbal; Koca, Gökhan; Korkmaz, Meliha

doi:10.1097/mnm.0000000000000788

Cited by 12 publications

(11 citation statements)

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“…Approximately 90% 131 I is excreted in the urine within 48 h of administration [21]. In the 131 I experimental trials, Nihat Yumusak et al [22] demonstrated that cell proliferation and apoptosis began on the seventh day and peaked during the tenth week based on the immunohistochemical analyses of the kidneys. Kolbert et al [23] provided dose-volume histograms and mean absorbed doses for 14 normal organs; the calculations were performed using a 3D voxelbased method.…”

Section: Discussionmentioning

confidence: 99%

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Yin

Wang

et al. 2021

Preprint

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Aim: This study aimed to investigate the effects of high-dose radioactive iodine (131I) treatment on the clinical metrics of renal function in patients with differentiated thyroid carcinoma (DTC).Patients and methods: The clinical metrics of renal function were analysed in 850 patients with DTC who received 131I therapy between January 2012 and December 2019. According to the baseline renal function metrics, the patients were divided into normal renal function group (group A) and abnormal renal function group (group B). Each group was further divided into three subgroups (subgroups 1, 2, and 3) based on the cumulative dose of 131I. The clinical metrics of renal function including serum creatinine (SCr) levels, blood urea nitrogen (BUN) levels and estimated glomerular filtration rate (eGFR) were measured within 1 month before the initiation of 131I therapy, 1 year after the last therapy, and 5 years after the initial therapy. The changes in renal function metrics before and after 131I therapy were compared in each group.Result: In group A (588 patients), no significant difference in the mean levels of SCr and BUN and eGFR was observed in the three subgroups (P >0.05), regardless of gender, before the initial 131I therapy and 1 year after the last therapy. A total of 8, 3, and 2 patients presented with abnormal renal function after 131I treatment in subgroups 1, 2, and 3, respectively. No statistically significant difference was observed in the incidence of renal dysfunction among the three subgroups (P = 0.287). The mean age of patients with renal dysfunction was significantly greater than that of patients without renal dysfunction after 131I treatment. In group B, of the 262 patients with abnormal renal function, SCr and BUN levels were elevated in 168 and 155 patients, respectively, and eGFR <60 mL/min/1.73 m2 was found in 87 patients before the initial 131I therapy. No significant difference was observed in the parameters among the three subgroups. However, SCr and BUN levels were found to be increased in all subgroups 5 years after the initial 131I therapy, and they were positively correlated with the cumulative dose of 131I. The difference was statistically significant (P <0.05). Furthermore, eGFR was found to be decreased in all subgroups after 131I therapy, and it was negatively correlated with the cumulative dose of 131I. The difference was statistically significant (P <0.05). A gender bias was not observed in the changing trends of SCr and BUN levels and eGFR.Conclusion: Our findings suggest that the nephrotoxicity of high-dose 131I therapy, regardless of gender, is very low in patients with DTC with normal renal function; however, high-dose 131I therapy may exacerbate the loss of renal function in those with renal dysfunction.

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Section: Discussionmentioning

confidence: 99%

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Yin

Wang

et al. 2021

Preprint

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“…Programmed cell death, also known as apoptosis, plays a vital role in regulating the cell number of human body and function of organs31623. The major mechanism for cell injury and damage caused by ionizing radiation is regarded as being the radiation-induced apoptosis816.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 (¹³¹I) irradiation

Li¹,

Xie²,

Qin³

et al. 2019

Indian J Med Res

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Background & objectives: The nature of adaptable change of B-cell lymphoma-2 ( BCL-2 ) and/or Bcl2-associated X protein ( BAX ) gene expression in the human peripheral blood mononuclear cells (PBMCs) irradiated by radioiodine in thyroid diseases therapy is not fully understood. In this study, the alternation of apoptotic gene expression was evaluated while the PBMCs collected from healthy volunteers were irradiated by the radioiodine-131 ( 131 I). Methods: Fasting blood samples were obtained from healthy volunteers. PBMCs from group 0 to 6 were incubated and exposed to different doses of 131 I in cell suspension for 6, 12, 24 and 48 h. The apoptosis rates and expression of BCL-2 and BAX genes of PBMCs were examined. Results: The apoptosis rate in the human PBMCs was gradually enhanced after six hour irradiation. The values of BCL-2 and BAX gene expression in groups 1-6 were higher than in group 0 within 6 h of irradiation, and then, these were decreased gradually from 6 to 12 h. BCL -2 gene expression increased in groups 1-3 after 12 h irradiation, but there was no difference in groups 4-6. The ratio of BCL-2 / BAX gene expression among groups 4-6 gradually decreased during the period from 6 to 12 h, and it was significantly lower than in the group 0 at 12, 24 and 48 h. Interpretation & conclusions: The expression of BCL-2 and BAX genes was initially upregulated following irradiation. Later, the balance of BCL-2 / BAX genes expression was adjusted, and then, PBMCs underwent apoptosis at higher doses of radiation.

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“…Approximately 90% of 131 I is excreted in the urine within 48 h of administration [22]. In the 131 I experimental trials, Nihat Yumusak et al [23] demonstrated that cell proliferation and apoptosis began on the seventh day and peaked during the tenth week based on immunohistochemical analyses of the kidneys. Kolbert et al [24] provided dose-volume histograms and mean absorbed doses for 14 normal organs; the calculations were performed using a 3D voxel-based method.…”

Section: Original Papermentioning

confidence: 99%

Effects of high-activity radioactive iodine treatment on renal function in patients with differentiated thyroid carcinoma — retrospective study

Yin

Li²,

Lv³

et al. 2022

Endokrynol Pol

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ence of residual, unresectable, and metastatic disease [1-3]. 131 I therapy has been successfully applied for more than 60 years for the management of DTC. Various studies have proven that ablative 131 I therapy significantly reduces the frequency of recurrences and tumour spread in patients with thyroid cancer. In patients with distant metastases, approximately 50% complete response may be achieved with 131 I treatment [4].The well-known possible side effects of high-activity 131 I therapy include radiation thyroiditis, nausea, vom-

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Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Abstract: Radioiodine caused cell proliferation and apoptosis as shown by immunohistochemistry.

Cited by 12 publications

References 20 publications

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 (¹³¹I) irradiation

Effects of high-activity radioactive iodine treatment on renal function in patients with differentiated thyroid carcinoma — retrospective study

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Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Abstract: Radioiodine caused cell proliferation and apoptosis as shown by immunohistochemistry.

Cited by 12 publications

References 20 publications

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study

Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 (131I) irradiation

Effects of high-activity radioactive iodine treatment on renal function in patients with differentiated thyroid carcinoma — retrospective study

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Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 (¹³¹I) irradiation