Apoprotein A-I and High Density Lipoprotein Subtractions in Patients with Chronic Renal Failure Receiving Hemodialysis

Joven, Jorge; Rubiés-Prat, J; Espinel, Eugènia; Chacón, Pedro Méndez; Olmos, A; Masdéu, S

doi:10.1159/000183518

Cited by 15 publications

(4 citation statements)

References 8 publications

(8 reference statements)

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“…The pattern o f hyperlipoproteinemia in patients with nephrotic syndrome is not completely understood and con flicting results have been described [8][9][10][11][12][16][17][18][19]. To explain this disagreement, several possibilities arise but the most probable is the misleading effect of frequently concomitant complications such as renal failure and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

“…In our uremic patients, the lipid distribution o f H D L was significantly different from that observed in the other nephrotic patients with significantly lower H D L cholesterol values. This is the more controver sial aspect o f the pattern of hyperlipidemia in the nephrotic syndrome, and different authors have reported high, low and normal H D L cholesterol values [16][17][18][19]. High levels have been interpreted as the result o f high serum lipopro tein (a) levels in the nephrotic syndrome contaminating the H D L samples when cholesterol is assayed [23].…”

Section: Discussionmentioning

confidence: 99%

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Pattern of Hyperlipoproteinemia in Human Nephrotic Syndrome: Influence of Renal Failure and Diabetes mellitus

Joven¹,

Villabona²,

Vilella³

1993

Nephron

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Forty-two patients with the nephrotic syndrome were grouped according to the absence or presence of renal failure and/or diabetes mellitus. All patients had a similar degree of hypoalbuminemia and urinary protein losses. A lipid and apoprotein pattern was generated in serum and ultracentrifugally isolated lipoproteins. Low-density lipoprotein composition was essentially normal in uremic patients while in the other patients with the nephrotic syndrome, a considerable lipid enrichment was noted. The very-low-density lipoprotein content in lipids was uniformly increased in nephrotic patients irrespective of the presence of complications. High-density lipoprotein cholesterol and serum apolipoprotein A I and E concentration was significantly reduced in uremic patients with respect to normal subjects and to the other groups considered. Serum apolipoprotein A II and B levels were also decreased in uremics. All patients had increased serum apoprotein C II and C III concentration. We conclude that diabetes mellitus does not affect the pattern of hyperlipoproteinemia of nephrotic syndrome while the characteristic lipoprotein and apoprotein pattern of uremia is present irrespective of nephrosis in uremic, nondiabetic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pattern of Hyperlipoproteinemia in Human Nephrotic Syndrome: Influence of Renal Failure and Diabetes mellitus

Joven¹,

Villabona²,

Vilella³

1993

Nephron

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“…In our experi ence glucose intolerance is still present in over 50% of the patients on RDT [57], mainly in patients who had started dialysis with very low residual renal function and fol lowing long-lasting treatment with low-pro tein diet [70], Hyperdyslipidemia Some 70% of patients with chronic renal failure exhibit abnormalities of the lipid pat tern [71][72][73][74] which are not modified at all by RDT [75,76]. The phenotypic features of uremic (or dialysis) hyperlipidemia include high total triglyceride and normal or low to normal total cholesterol and lower HDL cho lesterol levels, a corresponding increase in very-low-density lipoproteins and interme diate-density lipoproteins with a decrease in high-density lipoproteins, and, finally, changes of both lipid and apoprotein compo sition of lipoprotein particles [77,78].…”

Section: Glucose Intolerancementioning

confidence: 99%

Hormonal Changes in Hemodialysis

Bonomini¹,

Orsoni²,

Sorrentino³

et al. 1990

Blood Purif

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When chronic renal failure becomes advanced, the serum or tissue levels and/or the functions of most hormones are altered because of several interplaying mechanisms involving synthesis, transport, accumulation of inhibitors, abnormality of target organ responsiveness, and impaired renal clearance. As regular dialysis treatment is performed, most of these uremic hormone abnormalities are not reversed, and some of them may even get worse. The main endocrine derangements can be grouped as sexual hormone dysfunction, thyroid abnormalities, growth retardation, hormone-related disorders of metabolism, derangements of pressor substances, gastrointestinal peptide abnormalities, renal osteodystrophy, and anemia. The endocrine abnormalities play a major role as for the clinical and metabolic rehabilitation of dialysis patients.

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“…During recent years, with increasing knowledge and information gained from a number of studies, it becomes clear that the predominant change in lipoprotein is qualitative rather than quantitative [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Treatment of Secondary Hyperparathyroidism on the Lipid Profile in Patients on Hemodialysis

Lim¹,

Hung²,

Yeh³

et al. 1998

Blood Purif

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Abnormalities in circulating lipoprotein concentrations are a characteristic finding in patients undergoing dialytic therapy. A substantial number of these patients display type IV hyperlipoproteinemia. Certain data suggest that secondary hyperparathyroidism may induce disturbances in lipid metabolism. To evaluate the effects of pulse calcitriol therapy on the lipid profile in these patients, we undertook a prospective study in 12 patients on stable bicarbonate hemodialysis. Lipid parameters comprising cholesterol and the low- as well as the high-density lipoprotein subfractions, triglycerides, apolipoproteins A and B, serum parathyroid hormones (iPTH), alkaline phosphatase, calcium, phosphorus, hematocrit, and blood urea were obtained prior to commencement of pulse calcitriol therapy and again 8–10 weeks later. Calcitriol therapy was associated with a decrease in serum iPTH levels (701 ± 103.9 vs. 220.3 ± 50.5 pmol/l; p < 0.001). Significant increases in high-density lipoprotein cholesterol (32.8 ± 2.7 vs. 38.8 ± 2.3 mmol/l; p < 0.05) and apolipoprotein A-I (107.8 ± 6.1 vs. 121.8 ± 5.8 g/l; p < 0.05) were noted during the course of the study. Moreover, serum iPTH correlated inversely with high-density lipoprotein cholesterol and apolipoprotein A-I. There were no changes in other lipid parameters except for low-density lipoprotein cholesterol which showed a tendency to increase. We conclude that in short-term study, pulse oral calcitriol therapy is associated with an improvement in the lipid profile in patients with secondary hyperparathyroidism. However, it remains to be established whether ameliorating the uremic dyslipidemia results in any long-term clinical benefits.

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Apoprotein A-I and High Density Lipoprotein Subtractions in Patients with Chronic Renal Failure Receiving Hemodialysis

Cited by 15 publications

References 8 publications

Pattern of Hyperlipoproteinemia in Human Nephrotic Syndrome: Influence of Renal Failure and Diabetes mellitus

Pattern of Hyperlipoproteinemia in Human Nephrotic Syndrome: Influence of Renal Failure and Diabetes mellitus

Hormonal Changes in Hemodialysis

Effects of Treatment of Secondary Hyperparathyroidism on the Lipid Profile in Patients on Hemodialysis

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