Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee

Abstract

Since young adult Cherokee are at increased risk for both diabetes and cardiovascular disease, we assessed association of apolipoproteins (A-I, B, and C-III in non-HDL and HDL) with obesity and related risk factors. Obese participants (BMI ≥ 30) aged 20–40 years (n = 476) were studied. Metabolically healthy obese (MHO) individuals were defined as not having any of four components of the ATP-III metabolic syndrome after exclusion of waist circumference, and obese participants not being MHO were defined as metabolically abnormal obese (MAO). Associations were evaluated by correlation and regression modeling. Obesity measures, blood pressure, insulin resistance, lipids, and apolipoproteins were significantly different between groups except for total cholesterol, LDL-C, and HDL-apoC-III. Apolipoproteins were not correlated with obesity measures with the exception of apoA-I with waist and the waist : height ratio. In a logistic regression model apoA-I and the apoB : apoA-I ratio were significantly selected for identifying those being MHO, and the result (C-statistic = 0.902) indicated that apoA-I and the apoB : apoA-I ratio can be used to identify a subgroup of obese individuals with a significantly less atherogenic lipid and apolipoprotein profile, particularly in obese Cherokee men in whom MHO is more likely.

The Correlation between Apolipoprotein B Level and Inflammatory Markers in Obese

“…Insulin resistance, measured with the homeostasis index (HOMA-IR), correlated with apoB in this study supports the association of insulin resistance with lipoprotein transport. The results of the present study are in agreement with the previous study on 476 subjects, demonstrating that apoB correlated with insulin resistance (HOMA-IR) [12].…”

Relevance of obesity and overweight to salivary and plasma proteomes of human young adults from Brazil / Relevância da obesidade e sobrepeso para os proteomas salivares e plasmáticos de adultos jovens humanos do Brasil

“…Recently, apolipoproteins were associated to a higher risk for DM2. A strong association of apolipoprotein with BMI has already been demonstrated with a decrease in its concentration in overweight individuals (Wang, Blackett, Khan & Lee 2017). Some studies have observed a significantly BMI-related increase but with decrease in overweight individuals in the APOH protein levels in DM2 individuals compared to healthy individuals (Gómez- Cardona et al, 2017).…”

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

“…A possible hypothesis is that the improvement in psychopathology that accompanies changes in ApoA1 and ApoB levels may be a side effect indicating the efficacy of antipsychotic drugs, similar to the effect of antipsychotic-induced weight gain [ 51 , 71 ]. A number of literatures have revealed that obesity increases the ApoB /ApoA1 ratio [ 72 ] and that ApoA1 levels were positively associated with the risk of metabolically healthy obesity (MHO), but the ApoB /ApoA1 ratio is negatively associated [ 73 ].…”