ApolipoproteinA1-75 G/A (M1-) polymorphism and Lipoprotein(a); Anti- vs. Pro-Atherogenic properties

Abstract

Background: ApolipoproteinA1(apoA1) is the major apoprotein constituent of high-densitylipoprotein(HDL). The relationship of apoA1 -75 bp(M1 -) allele polymorphism with lipoprotein phenotype and cardiovascular diseae (CVD) remain unclear.

Abdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A‐I determine marked cardiometabolic risk

“…Aggregation of apoA‐I to Lp(a) is thus well possible during pro‐oxidative state. An association of significantly higher Lp(a) levels with the MI‐(G/A) allele of the apoA‐I‐75 bp polymorphism has been reported in Omani people irrespective of gender and diabetes .…”

Lipid Transport Genetic Polymorphism and Angiotensin-Converting Enzyme I/D Genetic Polymorphism in Uzbek Patients With Unstable Angina and Coronary Heart Disease in Family History

“…У женщин-носителей А аллеля была обнаружена взаимосвязь между генотипом и диетой, зависящая от АпоА1 G-A полиморфизма: повышенное потребление полиненасыщенных жирных кислот ассоциировалось с повышением концентрации ЛВП у женщин с А-аллелью, тогда как у женщин с G/G генотипом наблюдался противоположный эффект. В некоторых исследованиях было обнаружено, что носительство А-аллели (М1-) в промотерном регионе гена апоАI ассоциируется с достоверным повышением концентрации ЛП (а), независимо от пола и наличия СД [9,10]. Также в некоторых экспериментальных исследованиях было показано, что А аллель связана со снижением транскрипции апоА1, который, как известно, имеет антиатерогенное значение.…”

Features of gene polymorphisms regulating lipid metabolism and ID polymorphism of ACE gene in Uzbek patients with unstable angina with a family history of coronary heart disease

“…In women, carriers of the A allele was found the relationship between genotype and diet, depending on Apo AI GA polymorphism: increased intake of polyunsaturated fatty acids was associated with an increased concentration of HDL, whereas in women with G / G genotype was observed adverse effect (Ordovas, 1999). In some studies it was found that carriers of the A allele (M1) in the promoter region of Apo AI gene is associated with a significant increase in the concentration of lipoprotein (a), regardless of gender and the presence of diabetes (Albahrani et al, 2007;Heng et al, 2001). Also, in some experimental studies have shown that the A allele is associated with reduced transcription of lipoprotein AI, which is known to have important antiatherogenic value (Matsunaga et al, 1999;Smith et al, 1992;Tuteja et al, 1992).…”