Apolipoprotein E Phenotype Frequency and Cerebrospinal Fluid Concentration Are Not Associated With Creutzfeldt-Jakob Disease

Abstract

We found no significant difference in the distribution of Apo E phenotypes between patients with CJD and controls. The concentration of Apo E in cerebrospinal fluid cannot be taken as a biochemical marker for the disease. The Apo E phenotype had no influence on the duration of CJD. Our data do not support an association of Apo E4 with either the duration or time at onset of CJD.

Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients

“…Contradictory results exist in the literature regarding the frequency and association of the ApoE genotype with sCJD. While some authors consider that there is no association between ApoE genotype and sCJD [20,31,44], others postulate that ApoE-e4 allele is an independent risk factor for sCJD [1,37]. The discrepancy between our results and those stated above, can be due to the different control populations considered (other neurological condition with a clinical suspicion of sCJD vs. healthy subjects), and also to regional differences in the frequency of the ApoE genotypes [3,23].…”

Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients

“…Contradictory results exist in the literature regarding the frequency and association of the ApoE genotype with sCJD. While some authors consider that there is no association between ApoE genotype and sCJD [20,31,44], others postulate that ApoE-e4 allele is an independent risk factor for sCJD [1,37]. The discrepancy between our results and those stated above, can be due to the different control populations considered (other neurological condition with a clinical suspicion of sCJD vs. healthy subjects), and also to regional differences in the frequency of the ApoE genotypes [3,23].…”

ApoE Distribution and Family History in Genetic Prion Diseases in Germany

“…However, we cannot prove this hypothesis by our data because of the relatively low number of E4 allele carriers in our study. Similarly to previous studies, we could not find any relation between ApoE genotype and sex, age at onset or codon 129 genotype (Chapman et al 1998;Van Everbroeck et al 1999;Zerr et al 1996). While three of the 20 gPD patients (15%) with PFH of gPD were carriers of the AD-protective E2 allele, none of 8 the gPD patients with PFH of isolated dementia over more than 2 years had an E2 allele.…”

“…An association between ApoE4 and CJD has been controversially discussed. While a significantly higher frequency of ApoE4 allele carriers both in sCJD and gPD compared to controls was reported (Amouyel et al 1994;Van Everbroeck et al 1999), other studies found no significant difference of ApoE genotypes or ApoE4 allele frequency between sCJD/gPD patients and controls in other studies (Chapman et al 1998;Nakagawa et al 1995;Salvatore et al 1995;Zerr et al 1996). In the present study, the analysis of the ApoE distribution in German gPD patients revealed no significant differences between gPD patients and nondemented controls.…”

Characterization of four lipoprotein classes in human cerebrospinal fluid

“…The CSF cholesterol level of 0.6 mg/dl was comparable to values in the literature (0.2-0.8 mg/dl) (16,15,34,45,46). Also, the apoE and apoA-I levels in CSF (0.3 and 0.37 mg/dl, respectively) corresponded well with published data, which indicate 0.3-0.6 mg/dl for apoE (16,(47)(48)(49) and 0.45 mg/dl for apoA-I (50). Total fatty acids were measured by gas chromatography and the value obtained was 2.3 mg/dl, comparable to the normal value of 2 mg/dl in the literature (51).…”

Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients

“…Contradictory results exist in the literature regarding the frequency and association of the ApoE genotype with sCJD. While some authors consider that there is no association between ApoE genotype and sCJD [20,31,44], others postulate that ApoE-e4 allele is an independent risk factor for sCJD [1,37]. The discrepancy between our results and those stated above, can be due to the different control populations considered (other neurological condition with a clinical suspicion of sCJD vs. healthy subjects), and also to regional differences in the frequency of the ApoE genotypes [3,23].…”

ApoE Distribution and Family History in Genetic Prion Diseases in Germany

“…However, we cannot prove this hypothesis by our data because of the relatively low number of E4 allele carriers in our study. Similarly to previous studies, we could not find any relation between ApoE genotype and sex, age at onset or codon 129 genotype (Chapman et al 1998;Van Everbroeck et al 1999;Zerr et al 1996). While three of the 20 gPD patients (15%) with PFH of gPD were carriers of the AD-protective E2 allele, none of 8 the gPD patients with PFH of isolated dementia over more than 2 years had an E2 allele.…”

“…An association between ApoE4 and CJD has been controversially discussed. While a significantly higher frequency of ApoE4 allele carriers both in sCJD and gPD compared to controls was reported (Amouyel et al 1994;Van Everbroeck et al 1999), other studies found no significant difference of ApoE genotypes or ApoE4 allele frequency between sCJD/gPD patients and controls in other studies (Chapman et al 1998;Nakagawa et al 1995;Salvatore et al 1995;Zerr et al 1996). In the present study, the analysis of the ApoE distribution in German gPD patients revealed no significant differences between gPD patients and nondemented controls.…”

Characterization of four lipoprotein classes in human cerebrospinal fluid

“…The CSF cholesterol level of 0.6 mg/dl was comparable to values in the literature (0.2-0.8 mg/dl) (16,15,34,45,46). Also, the apoE and apoA-I levels in CSF (0.3 and 0.37 mg/dl, respectively) corresponded well with published data, which indicate 0.3-0.6 mg/dl for apoE (16,(47)(48)(49) and 0.45 mg/dl for apoA-I (50). Total fatty acids were measured by gas chromatography and the value obtained was 2.3 mg/dl, comparable to the normal value of 2 mg/dl in the literature (51).…”

Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients

“…Contradictory results exist in the literature regarding the frequency and association of the ApoE genotype with sCJD. While some authors consider that there is no association between ApoE genotype and sCJD [20,31,44], others postulate that ApoE-e4 allele is an independent risk factor for sCJD [1,37]. The discrepancy between our results and those stated above, can be due to the different control populations considered (other neurological condition with a clinical suspicion of sCJD vs. healthy subjects), and also to regional differences in the frequency of the ApoE genotypes [3,23].…”

ApoE Distribution and Family History in Genetic Prion Diseases in Germany

“…However, we cannot prove this hypothesis by our data because of the relatively low number of E4 allele carriers in our study. Similarly to previous studies, we could not find any relation between ApoE genotype and sex, age at onset or codon 129 genotype (Chapman et al 1998;Van Everbroeck et al 1999;Zerr et al 1996). While three of the 20 gPD patients (15%) with PFH of gPD were carriers of the AD-protective E2 allele, none of 8 the gPD patients with PFH of isolated dementia over more than 2 years had an E2 allele.…”

“…An association between ApoE4 and CJD has been controversially discussed. While a significantly higher frequency of ApoE4 allele carriers both in sCJD and gPD compared to controls was reported (Amouyel et al 1994;Van Everbroeck et al 1999), other studies found no significant difference of ApoE genotypes or ApoE4 allele frequency between sCJD/gPD patients and controls in other studies (Chapman et al 1998;Nakagawa et al 1995;Salvatore et al 1995;Zerr et al 1996). In the present study, the analysis of the ApoE distribution in German gPD patients revealed no significant differences between gPD patients and nondemented controls.…”

Characterization of four lipoprotein classes in human cerebrospinal fluid

“…The CSF cholesterol level of 0.6 mg/dl was comparable to values in the literature (0.2-0.8 mg/dl) (16,15,34,45,46). Also, the apoE and apoA-I levels in CSF (0.3 and 0.37 mg/dl, respectively) corresponded well with published data, which indicate 0.3-0.6 mg/dl for apoE (16,(47)(48)(49) and 0.45 mg/dl for apoA-I (50). Total fatty acids were measured by gas chromatography and the value obtained was 2.3 mg/dl, comparable to the normal value of 2 mg/dl in the literature (51).…”