Apolipoprotein E Genotypes and Serum Lipid Levels in Alzheimer's Disease and Multi-Infarct Dementia

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi’an, China

“…One study found that high LDL-C was negatively correlated with cognitive impairment [24], one showed the correlation was opposite [25]. The relationship between serum HDL-C levels and cognitive impairment remained unclear [26, 27]. One suggested an association between lower HDL-C levels and poor cognitive function [28], while another reported that HDL-C levels were not related to cognitive function [29].…”

Serum high-density lipoprotein cholesterol levels correlate well with functional but not with cognitive status in 85-year-old subjects

“…However, the relationship between HDL-C and cognitive status merits more detailed discussion because there is no consensus on this topic. Indeed, the role of HDL-C in the risk for and progression of cognitive impairment remains unclear, not to say controversial ( 29 ). Few studies have evaluated the association between dementia and specific lipoprotein fractions, although some authors have reported that low HDL-C is correlated with cognitive impairment and dementia, suggesting that part of this association might be independent of atherosclerotic disease ( 30 , 31 ).…”

Cholesterol, APOE genotype, and Alzheimer disease

“…Other studies have also found no association between triglyceride levels and AD risk but did not stratify for APOE. [35][36][37][38][39][40][41] Triglycerides are associated with an increased risk of coronary artery disease, particularly in women and patients with diabetes. 41,42 However, the association between triglycerides and risk of coronary artery disease has been difficult to demonstrate because there is a larger daily variation in fasting triglycerides (20 to 30%) and not all triglyceride-rich lipoproteins are atherogenic.…”