2012
DOI: 10.3233/jad-2012-111568 View full text |Buy / Rent full text
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Abstract: Apolipoprotein E [ApoE, APOE (gene)] is a multifunctional protein of the lipid and lipoprotein transport system mainly involved in metabolism of dietary lipids. Its polymorphic variants are considered a genetic risk factor of cognitive impairment in several neurodegenerative disorders such as Lewy body dementia, Huntington's disease, and Alzheimer's disease, as well as in vascular dementia and cerebrovascular disease. The precise mechanism by which APOE affects neurodegeneration is still unclear. Epidemiologic… Show more

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“…We examined age, sex, education, CRF, and APOE‐ε4 as modifiers of the association between MetS and CI based on previous literature . Refuting our hypotheses, none of these factors modified the MetS‐CI association in our study population, although the null findings are potentially attributable to specific characteristics of our study population.…”
Section: Discussionmentioning
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“…We examined age, sex, education, CRF, and APOE‐ε4 as modifiers of the association between MetS and CI based on previous literature . Refuting our hypotheses, none of these factors modified the MetS‐CI association in our study population, although the null findings are potentially attributable to specific characteristics of our study population.…”
Section: Discussionmentioning
“…Overall, we hypothesized that MetS would be associated with a higher prevalence of CI and the association would attenuate when adjusting for confounders beyond sociodemographic characteristics. Based on previous literature, we also examined age, sex, education, CRF, and APOE‐ε4 as modifiers to explore the complex MetS‐CI association . We hypothesized that participants with MetS aged 75 years and older would have a lower prevalence of CI and the positive MetS‐CI association would be strongest among those with the least education, those who were APOE‐ε4 carriers, and those with the lowest CRF.…”
Section: Introductionmentioning
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“…APOE4 exhibits multifunctionality in lipid and lipoprotein transport systems, mainly in the metabolism of dietary lipids [15] . Carriers these traits in vitro.…”
Section: Apolipoprotein E4mentioning