Apolipoprotein e gene polymorphism as a risk factor for ischemic cerebrovascular disease

Stanković, Sanja; Jovanovic-Markovic, Zagorka; Majkić-Singh, Nada; Stanković, D; Glišić, Sanja; Živković, Maja; Kostić, Smiljana; Alavantić, Dragan

doi:10.2298/jmh0403255s

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…McCarron et al [102] found a favorable effect of the ε4 allele on stroke outcome. Stankovic and colleagues [85] reviewed the conflicting results on the importance of the apo alleles in predisposition to IS.…”

Section: Candidate-gene Association Studies Of Ischemic Strokementioning

confidence: 99%

“…Approximately half of all casecontrol studies [26,27,29,33,38,41,45,47,49,51,53,54,57,58,60,64,67,69,71,[73][74][75][76][78][79][80]82,84,85,[89][90][91][93][94][95][96]99,100] showed an increased frequency of the ε4 allele in stroke patients, making it a highly probable risk factor for IS; in four, significant association with large-vessel IS was observed. Three groups described the 2 allele as a risk factor for IS [76,85,94].…”

Section: Candidate-gene Association Studies Of Ischemic Strokementioning

confidence: 99%

“…Three groups described the 2 allele as a risk factor for IS [76,85,94]. The status of the E2/3 genotype as a protective or risk factor is controversial.…”

Section: Candidate-gene Association Studies Of Ischemic Strokementioning

confidence: 99%

See 2 more Smart Citations

Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies

Stanković¹,

Ašanin²,

Majkić-Singh³

2012

Lipoproteins - Role in Health and Diseases

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Section: Candidate-gene Association Studies Of Ischemic Strokementioning

confidence: 99%

Section: Candidate-gene Association Studies Of Ischemic Strokementioning

confidence: 99%

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Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies

Stanković¹,

Ašanin²,

Majkić-Singh³

2012

Lipoproteins - Role in Health and Diseases

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“…McCarron and colleagues found a favorable effect of E4 on stroke outcome. Stankovi} and colleagues (126) gave detailed description of the conflicting results as to the importance of apoE alleles in predisposition to ischemic stroke.…”

Section: Coagulation and Fibrinolytic System In Strokementioning

confidence: 99%

Genetic aspects of ischemic stroke

Stanković¹,

Majkić-Singh²

2005

Jugoslav Med Biohem

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Stroke is one of the most common causes of death and long term disability throughout the world. It is not only induced by classic vascular risk factors like hypertension, cigarette smoking and diabetes mellitus, but also by genetic factors. The genetic etiology of ischemic stroke is polygenic. The candidate »stroke risk« genes may be conveniently divided into five groups, affecting (i) lipid metabolism, (ii) the renin-angiotensin system, (iii) haemostasis, (iv) nitric oxide production, and (v) homocysteine metabolism. Since stroke is a complex disease comprising a heterogeneous group of disorders with multiple risk factors, research into genetics of stroke presents some unique challenges. Numerous studies have investigated the role of genetics in the pathogenesis of stroke, with varied and often contradictory results. Additional knowledge of the role of genes in ischemic stroke may improve our understanding of the cause of stroke, provide new insights into prevention and the factors that influence the outcome of stroke, and new therapeutic targets when preventive strategies have failed.

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Apolipoprotein E ε4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction. Rising studies indicate that the apolipoprotein E (APOE) gene is related to the susceptibility of ischemic stroke (IS). However, certain consensus is limited by the lack of a large sample size of researches. This meta-analysis was performed to explore the potential association between the APOE gene and IS. Methods. To identify relevant case control studies in English publications by October 2020, we searched PubMed, Embase, Web of Science, and the Cochrane Library. Pooled odds ratios (ORs) with fixed- or random-effect models and corresponding 95% confidence intervals (CIs) were calculated to analyze potential associations. Results. A total of 55 researches from 32 countries containing 12207 IS cases and 27742 controls were included. The association between APOE gene ε4 mutation and IS was confirmed (ε4 vs. ε3 allele: pooled OR = 1.374 , 95% CI, 1.214-1.556; ε2/ε4 vs. ε3/ε3: pooled OR = 1.233 , 95% CI, 1.056-1.440; ε3/ε4 vs. ε3/ε3: pooled OR = 1.340 , 95% CI, 1.165-1.542; ε4/ε4 vs. ε3/ε3: pooled OR = 1.833 , 95% CI, 1.542-2.179; and APOE ε4 carriers vs. non-ε4 carriers: pooled OR = 1.377 ; 95% CI, 1.203-1.576). Interestingly, APOE ε4 mutation showed a dose-response correlation with IS risk (ε4/ε4 vs. ε2/ε4: pooled OR = 1.625 ; 95% CI, 1.281-2.060; ε4/ε4 vs. ε3/ε4: pooled OR = 1.301 ; 95% CI, 1.077-1.571). Similar conclusions were drawn in the small artery disease (SAD) subtype, but not in large artery atherosclerosis (LAA) or in cardioaortic embolism (CE), by subgroup analysis. Conclusions. These observations reveal that specific APOE ε4 mutation was significantly associated with the risk of IS in a dose-dependent manner, while APOE ε4 mutation was related to SAD subtype onset without a cumulative effect.

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Apolipoprotein e gene polymorphism as a risk factor for ischemic cerebrovascular disease

Cited by 5 publications

References 31 publications

Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies

Genetics of Ischemic Stroke: Emphasis on Candidate-Gene Association Studies

Genetic aspects of ischemic stroke

Apolipoprotein E ε4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis

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