Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women

Lambrinoudaki, Ιrene; Kaparos, George; Rizos, Demetrios; Galapi, Fotini; Alexandrou, Andreas; Sergentanis, Theodoros N.; Creatsa, Maria; Christodoulakos, George; Kouskouni, Evaggelia; Botsis, D.

doi:10.1111/j.1365-2265.2008.03476.x

Cited by 8 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that only a few studies concerning the impact of the APOE gene polymorphism on thyroid status are available in the literature. Our findings are in agreement with those of Lambrinoudaki et al [41] that also demonstrated lower levels of thyroid hormones in postmenopausal healthy women with a ε4 allele. So far, no pathophysiological mechanism responsible for this state has been established.…”

Section: Discussionsupporting

confidence: 83%

Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Bojar¹,

Stasiak²,

Cyniak-Magierska³

et al. 2016

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). Methods: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory. Results and Conclusion: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.

show abstract

Section: Discussionsupporting

confidence: 83%

Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Bojar¹,

Stasiak²,

Cyniak-Magierska³

et al. 2016

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…A study performed on healthy post-menopausal women with no pesticide exposure found a negative association between R allele of the polymorphism PON1 192 and free T3 levels [13]. Additionally, in male flower workers from a floricultural area of Mexico, our research group found a positive association between urine concentration of dialkylphosphate (DAP) OP metabolites and TSH and total T4 levels and a negative association with total T3 [6], as well as a decrease in the percentage of variation of TSH among carriers of PON1 192 RR genotype [8].…”

Section: Introductionmentioning

confidence: 99%

Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area

et al. 2019

View full text Add to dashboard Cite

Background Adequate maternal thyroxine (T4) concentrations during the first half of pregnancy are fundamental to the embryo’s or fetus’ neural development. Organophosphate pesticides (OP) can act as thyroid disruptors and genetic polymorphisms for paraoxonase 1 (PON1), an enzyme that detoxifies OP, could be involved in individual’s susceptibility to them. We assessed the association between para-occupational exposure to pesticides, including OP, during pregnancy and maternal hypothyroxinemia, as well as the potential genetic susceptibility conferred by PON1 polymorphisms. Methods We analyzed information from 381 healthy pregnant women (< 17 gestational weeks), who lived in a floricultural region of Mexico where pesticides, including OP, are routinely used. Women who were para-occupationally exposed to pesticides were those whose partner had an occupation involving contact with these products. Thyroid-Stimulating Hormone (TSH) and free T4 concentrations were determined using ELISA, and hypothyroxinemia was defined as free T4 concentrations <0.76 ng/dL. PON1192QR , PON155LM and PON1–108CT polymorphisms were determined through Polymerase Chain Reaction (PCR). The association between para-occupational exposure and genetic polymorphisms and hypothyroxinemia was estimated using logistic regression models. Results One hundred and sixty two women (42.52%) were classified as para-occupationally exposed to pesticides. Hypothyroxinemia prevalence was 54%, and it was not significantly associated with pesticide para-occupational exposure (OR: 1.21 95% CI 0.75–1.94). Independently of para-occupational exposure, the likelihood of hypothyroxinemia was higher among women who were carriers of PON155MM than in those with PON155LL genotype (OR MM vs LL : 3.03; 95%CI 1.62, 5.70). PON1192 RR (OR RR vs QQ : 1.72; 95%CI 0.93, 3.17) and PON1–108TT (OR TT vs CC : 1.60; 95%CI 0.90, 2.70) genotypes were marginally associated with hypothyroxinemia. No significant interaction was observed between pesticides para-occupational exposure and PON1 polymorphisms. Conclusions These results suggest that PON1 polymorphisms could affect thyroid function during pregnancy in women living in areas where pesticides, including OP, are routinely used. Low exposure variability in this population, could be a possible explanation for the lack of association between para-occupational exposure and thyroid function.

show abstract

“…Nevertheless, researchers have reported their attempts to combine genetic variants with different aspects of menopausal syndromes [ 3 , 5 , 6 , 32 ]. We selected two genes in our study: one for APOE and one for LEP , on the basis of biological conditions mentioned in [ 33 , 34 , 35 , 36 , 37 , 38 ] to be associated with menopause.…”

Section: Discussionmentioning

confidence: 99%

“…Perhaps the “other genotypes” group might not show this significant difference because the sample size of this group is smaller. Furthermore, Lambrinoudaki et al [ 35 ] observed in their pilot study that polymorphisms of APOE and paraoxonase 1 are associated with different levels of the thyroid hormone and anti-TG antibody levels in the study population. A statistically significant correlation was found between apolipoprotein E polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the APOE gene had lower levels of FT4 than women with the E3E3 genotype.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause

Rył

Jasiewicz

Grzywacz

et al. 2016

IJERPH

View full text Add to dashboard Cite

Background: Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. Methods: The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE) and lepitn (LEP) genotypes were determined by real-time PCR and polymerase chain reaction–restriction fragment length polymorphism, respectively. Results: We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. Conclusions: To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels.

show abstract

Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women

Abstract: Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti-Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.

Cited by 8 publications

References 33 publications

Cognitive Function, <b><i>APOE</i></b> Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Cognitive Function, <b><i>APOE</i></b> Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area

Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause

Contact Info

Product

Resources

About