Apolipoprotein E and Intronic Polymorphism of Presenilin 1 and Alpha-1-Antichymotrypsin in Alzheimer’s Disease and Vascular Dementia

Abstract

Apolipoprotein E (ApoE) genotypes, presenilin 1 (PS-1) and α1-antichymotrypsin (ACT) polymorphism and the association of the genotypes were examined in patients with Alzheimer’s disease (AD, n = 121) or vascular dementia (VD, n = 68) in comparison with elderly controls (n = 125). The frequency of the ApoE ε4 allele was significantly increased both in late-onset AD (0.35) and in VD (0.17); the frequency of ApoE ε2 was significantly reduced in AD, but it was similar in VD and controls. The presence of…