Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease

Ohwada, Takayuki; Sakamoto, Takayuki; Kanno, Yuki; Yokokawa, Sayoko; Amami, Kazuaki; Nakazato, Kazuhiko; Takeishi, Yasuchika; Watanabe, Kenichi

doi:10.1371/journal.pone.0212539

Cited by 11 publications

(6 citation statements)

References 23 publications

(22 reference statements)

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“…No correlation was found between apoA1 and the percentage of necrotic core volume of the target coronary artery lesion. In this population, the apoB level was a very good indicator of the size of necrotic core and a potential biomarker for unstable plaque with an advantage over LDL-C [ 127 ].…”

Section: Biomarkers For Cvd: Ldl-c and Apobmentioning

confidence: 99%

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target

et al. 2021

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Apolipoprotein (apo) B, the critical structural protein of the atherogenic lipoproteins, has two major isoforms: apoB48 and apoB100. ApoB48 is found in chylomicrons and chylomicron remnants with one apoB48 molecule per chylomicron particle. Similarly, a single apoB100 molecule is contained per particle of very-low-density lipoprotein (VLDL), intermediate density lipoprotein, LDL and lipoprotein(a). This unique one apoB per particle ratio makes plasma apoB concentration a direct measure of the number of circulating atherogenic lipoproteins. ApoB levels indicate the atherogenic particle concentration independent of the particle cholesterol content, which is variable. While LDL, the major cholesterol-carrying serum lipoprotein, is the primary therapeutic target for management and prevention of atherosclerotic cardiovascular disease, there is strong evidence that apoB is a more accurate indicator of cardiovascular risk than either total cholesterol or LDL cholesterol. This review examines multiple aspects of apoB structure and function, with a focus on the controversy over use of apoB as a therapeutic target in clinical practice. Ongoing coronary artery disease residual risk, despite lipid-lowering treatment, has left patients and clinicians with unsatisfactory options for monitoring cardiovascular health. At the present time, the substitution of apoB for LDL-C in cardiovascular disease prevention guidelines has been deemed unjustified, but discussions continue.

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Section: Biomarkers For Cvd: Ldl-c and Apobmentioning

confidence: 99%

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target

et al. 2021

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“…Adanya perubahan distensibilitas arteri karotis kemungkinan disebabkan oleh peningkatan kadar LDL-C dan apolipoprotein B (apoB). ApoB memiliki berat molekul yang amat kecil dan tergolong very-low density lipoprotein yang bisa menembus endotel vaskular, bersamaan dengan LDL-C yang merupakan penghantar utama kolesterol ke dalam dinding arteri sehingga mengakibatkan proses aterogenesis terjadi akibat akumulasi kolesterol di media intima sehingga muncul plaque yang mengakibatkan disfungsi vaskular 22 . ApoB diketahui lebih berpengaruh terhadap perkembangan plak vaskular dibandingkan kadar LDL-C dalam tubuh, karena itulah apoB dapat dijadikan salah satu biomarker adanya unstable plaque pada pasien, dan berhubungan dengan risiko tinggi penyakit kardiovaskular di masa yang akan datang 23 .…”

Section: Pengaruh Diet Ketogenik Terhadap Risiko Terjadinya Penyakit ...unclassified

Pengaruh Diet Ketogenik terhadap Ketebalan dan Elastisitas Arteri Karotis pada Pasien Epilepsi: A Systematic Review

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Octavia

et al. 2022

AMNT

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Background: Ketogenic diet is a high lipid, low carbohydrate, and adequate protein diet. It has long been used as a therapy in refractory epilepsy patients, but very little is known about the long-term effects. Objectives: This study was conducted to analyze the effect of a ketogenic diet on carotid artery thickness and elasticity in patients with epilepsy. Discussion: Literature searches were conducted through search engines such as PubMed, ScienceDirect, and Google Scholar, resulting in four studies that were eligible for inclusion and have passed the selection process based on PRISMA flowchart and JBI critical appraisal. These studies involved patients with refractory epilepsy (13 months to 31 years old), who were given ketogenic diet therapy for at least 6 months. Carotid artery elasticity decreased significantly on the ketogenic diet given for 12 months (p<0.001). However, it was not accompanied by a significant change in wall thickness, which was assessed through carotid intima-media thickness (CIMT). Most studies found an increased cardiovascular risk due to an increase in lipid profile and carotid artery stiffness. Conclusions: In conclusion, the ketogenic diet affects the carotid artery elasticity without changing the thickness, also increases lipid levels reversibly, and is thought to increase cardiovascular risk in patients with refractory epilepsy.

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“…In a meta-analysis [1] and several studies [2,3] that have investigated the plaque volume and vessel composition using virtual histology-intravascular ultrasound (VH-IVUS) during percutaneous coronary intervention (PCI) before and after taking statins, statins reduced the plaque volume [4] and percentage of necrotic core volume (%NC). Previously, we showed the correlation of the %NC with apolipoprotein B and low-density lipoprotein (LDL) cholesterol [5] . These effects are presumed to be partly due to the lowering of LDL cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein C3 and Necrotic Core Volume Are Correlated but Also Associated With Future Cardiovascular Events

Ohwada

Sakamoto

Suzuki

et al. 2022

Preprint

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We aimed to clarify the relationship between apolipoprotein C3 (apo-C3) and vascular composition of lesion plaque in stable coronary disease (SCD) before percutaneous coronary intervention (PCI) and to investigate major adverse cardiovascular events (MACEs) within 4 years. Data of 98 consecutive patients with SCD who underwent PCI between November 1, 2012, and March 10, 2015, were analyzed. Laboratory evaluation and virtual histology-intravascular ultrasound (VH-IVUS) examination of culprit lesions were conducted before PCI. Patients were divided according to the median apo-C3 value into low apo-C3 (≤8.5 mg/dL) and high apo-C3 (>8.5 mg/dL) groups. VH-IVUS data indicated that the percentage of necrotic core volume (%NC) was significantly higher in the high apo-C3 group than in the low apo-C3 group. Moreover, the %NC significantly correlated with the apo-C3 level (R=0.2109, P=0.037). Kaplan–Meier curve analysis revealed that freedom from MACEs decreased more in the high apo-C3 group than in the low apo-C3 group and in the high %NC group than in the low %NC group. Multivariate Cox hazards analysis showed that the %NC and high apo-C3 were independent predictors of 4-year MACEs. Apo-C3 may be a useful marker for future MACEs in patients with SCD after PCI and contribute to %NC growth.

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Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease

Cited by 11 publications

References 23 publications

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target

Pengaruh Diet Ketogenik terhadap Ketebalan dan Elastisitas Arteri Karotis pada Pasien Epilepsi: A Systematic Review

Apolipoprotein C3 and Necrotic Core Volume Are Correlated but Also Associated With Future Cardiovascular Events

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