volume 9, issue 3, P964-985 2017
DOI: 10.18632/aging.101203
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Laila Abdullah, James E. Evans, Tanja Emmerich, Gogce Crynen, Ben Shackleton, Andrew P. Keegan, Cheryl Luis, Leon Tai, Mary J. LaDu, Michael Mullan, Fiona Crawford, Corbin Bachmeier

Abstract: This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer's disease (AD). Lipidomic analyses were also performed on blood from an AD mouse model expressing human APOE isoforms (EFAD) and five AD mutations and from 195 cognitively normal participants, 23 of who converted to mild cognitive impairment (MCI)/AD within 3 years. APOE ε4-carriers converting to MCI/AD had high arachidonic acid (AA)/docosahexaenoic acid (DHA) ratios in PL…

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