“…Supporting the latter, autotaxin, an enzyme that produces lysophosphatidic acid from lysophosphatidylcholine in Lp(a) trapped in the extracellular matrix, promotes valvular calcification via inflammation and has been reported to be increased in CAVD 7. In contrast, Capoulade et al 3 did not find an association of autotaxin on Lp(a) or apoB with increased progression of aortic stenosis. The reason for this discrepancy is not clear, but some potential reasons could include that the present study assessed autotaxin mass but not activity, and only autotaxin on Lp(a) and apoB but not total plasma levels.…”