APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells

Xia, Hua; Liu, Yamin; Xu, Li; Mao, Huajie; Zhou, Qin; Xie, Yajun

doi:10.1007/s11626-021-00589-z

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…We conducted a literature review on DEmRNAs in the PPI submodules of the three lesion stages (Tables S1–S5, Supporting Information [ 15–42 ] ). All the DEmRNAs were confirmed to be associated with cancers.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Wei

et al. 2023

Advanced Biology

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The dynamic changes of key biological characteristics from gastric low‐grade intraepithelial neoplasia (LGIN) to high‐grade intraepithelial neoplasia (HGIN) to early gastric cancer (EGC) are still unclear, which greatly affect the accurate diagnosis and treatment of EGC and prognosis evaluation of gastric cancer (GC). In this study, bioinformatics methods/tools are applied to quantitatively analyze molecular characteristics evolution of GC progression, and a prognosis model is constructed. This study finds that some dysregulated differentially expressed mRNAs (DEmRNAs) in the LGIN stage may continue to promote the occurrence and development of EGC. Among the LGIN, HGIN, and EGC stages, there are differences and relevance in the transcription expression patterns of DEmRNAs, and the activation related to immune cells is very different. The biological functions continuously changed during the progression from LGIN to HGIN to EGC. The COX model constructed based on the three EGC‐related DEmRNAs has GC prognostic risk prediction ability. The evolution of biological characteristics during the development of EGC mined by the authors provides new insight into understanding the molecular mechanism of EGC occurrence and development. The three‐gene prognostic risk model provides a new method for assisting GC clinical treatment decisions.

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Section: Resultsmentioning

confidence: 99%

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Wei

et al. 2023

Advanced Biology

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“…Finally, the Apobec-1 complementation factor (A1CF) promoted progression of RCC through DKK1-MEK/ERK signaling pathway [ 387 ], without assessing RNA edition. The same group also described that A1CF promotes RCC cell migration by promoting nuclear translocation of SMAD3 [ 388 ]. A1CF overexpression correlated positively with SMAD3, Snail1, and N-cadherin expression [ 388 ].…”

Section: Molecular Alterations In Cancer Metastasismentioning

confidence: 99%

“…The same group also described that A1CF promotes RCC cell migration by promoting nuclear translocation of SMAD3 [ 388 ]. A1CF overexpression correlated positively with SMAD3, Snail1, and N-cadherin expression [ 388 ]. These two studies investigated the role of a co-factor of APOBEC1, suggesting that complementary studies are needed to determine if edition is altered in RCC.…”

Section: Molecular Alterations In Cancer Metastasismentioning

confidence: 99%

Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics

Janin

Dávalos

Esteller

2023

Cancer Metastasis Rev

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Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA modifiers, namely writers, readers, and erasers; enzymes responsible of respectively introducing, recognizing, or removing the epigenetic or epitranscriptomic modifications. Epigenetic regulation is achieved by DNA methylation, histone modifications, non-coding RNAs, chromatin accessibility, and enhancer reprogramming. In parallel, regulation at RNA level, named epitranscriptomic, is driven by a wide diversity of chemical modifications in mostly all RNA molecules. These two-layer regulatory mechanisms are finely controlled in normal tissue, and dysregulations are associated with every hallmark of human cancer. In this review, we provide an overview of the current state of knowledge regarding epigenetic and epitranscriptomic alterations governing tumor metastasis, and compare pathways regulated at DNA or RNA levels to shed light on a possible epi-crosstalk in cancer metastasis. A deeper understanding on these mechanisms could have important clinical implications for the prevention of advanced malignancies and the management of the disseminated diseases. Additionally, as these epi-alterations can potentially be reversed by small molecules or inhibitors against epi-modifiers, novel therapeutic alternatives could be envisioned.

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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells

Cited by 2 publications

References 40 publications

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics

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