Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats

Hussein, Marwa M.; Althagafi, Hussam A.; Alharthi, Fahad; Albrakati, Ashraf; Alsharif, Khalaf F.; Theyab, Abdulrahman; Kassab, Rami B.; Mufti, Ahmad H.; Algahtani, Mohammad; Oyouni, Atif Abdulwahab A.; Baty, Roua S.; Moneim, Ahmed E. Abdel; Lokman, Maha S.

doi:10.1007/s11356-022-20235-9

Cited by 11 publications

(8 citation statements)

References 80 publications

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“…Administration of apigenin decreases oxidative stress parameters and protects against mitochondrial damage [ 70 ]. Moreover, apigenin protects against gentamicin-induced renal impairments by restoring enzymatic and non-enzymatic antioxidant proteins, including SOD, glutathione reductase (GR), CAT, GPx, and reduced GSH [ 71 ].…”

Section: Nephroprotective Effects Of Flavonoidsmentioning

confidence: 99%

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Alsawaf

Alnuaimi

Afzal

et al. 2022

Biology

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The kidney is susceptible to reactive oxygen species-mediated cellular injury resulting in glomerulosclerosis, tubulointerstitial fibrosis, tubular cell apoptosis, and senescence, leading to renal failure, and is a significant cause of death worldwide. Oxidative stress-mediated inflammation is a key player in the pathophysiology of various renal injuries and diseases. Recently, flavonoids’ role in alleviating kidney diseases has been reported with an inverse correlation between dietary flavonoids and kidney injuries. Flavonoids are plant polyphenols possessing several health benefits and are distributed in plants from roots to leaves, flowers, and fruits. Dietary flavonoids have potent antioxidant and free-radical scavenging properties and play essential roles in disease prevention. Flavonoids exert a nephroprotective effect by improving antioxidant status, ameliorating excessive reactive oxygen species (ROS) levels, and reducing oxidative stress, by acting as Nrf2 antioxidant response mediators. Moreover, flavonoids play essential roles in reducing chemical toxicity. Several studies have demonstrated the effects of flavonoids in reducing oxidative stress, preventing DNA damage, reducing inflammatory cytokines, and inhibiting apoptosis-mediated cell death, thereby preventing or improving kidney injuries/diseases. This review covers the recent nephroprotective effects of flavonoids against oxidative stress-mediated inflammation in the kidney and their clinical advancements in renal therapy.

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Section: Nephroprotective Effects Of Flavonoidsmentioning

confidence: 99%

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Alsawaf

Alnuaimi

Afzal

et al. 2022

Biology

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“…Antioxidants are substances that reduce ROS levels by modifying glucose, lipid, and amino acid homeostasis pathways and decreasing inflammation. 12 Total antioxidant capacity, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities can all be used to establish the animal’s oxidative status. A crucial transcription factor that regulates the antioxidant response is nuclear factor erythroid 2-related factor 2 (Nrf2) 13 via controlling the expression of several phase II detoxifying and antioxidant enzymes, including GPx, SOD, catalase, heme oxygenase-1, glutamate-cysteine ligase, and glutathione S -transferase.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, scientists began to focus their efforts on natural bioactive substances with antiobesity and antioxidant properties with no side effects. Antioxidants are substances that reduce ROS levels by modifying glucose, lipid, and amino acid homeostasis pathways and decreasing inflammation . Total antioxidant capacity, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities can all be used to establish the animal’s oxidative status.…”

Section: Introductionmentioning

confidence: 99%

Lycopene Effects on Metabolic Syndrome and Kidney Injury in Rats Fed a High-Fat Diet: An Experimental Study

Albrahim

Robert

2022

ACS Omega

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The frequency of overweight and obesity is rising globally. These disorders are prevalent health problems. It has a substantial correlation with a number of health issues, including cardiovascular, metabolic, and diabetes mellitus disorders. Lycopene (Lyc) is an acyclic structural isomer of β-carotene and has powerful antioxidant properties with various promising therapeutic effects. In this study, rats fed a high-fat diet were examined to determine how lycopene affected metabolic syndrome and kidney damage. After being acclimated, rats were divided into 5 groups ( n = 8/group) as follows: the first group served as the control and was fed on a normal pelleted diet (4.25% fat) until the end of the experiment. The second group (high-fat diet; HFD) was fed on a high-fat diet (45.5 kcal% fat) composed of 24% fat, 24% protein, and 41% carbohydrate. The third and fourth groups were fed on HFD and administered lycopene at 25 and 50 mg/kg bodyweight orally every day. The fifth group (standard drug group) received HFD and simvastatin (SVS; 10 mg/kg bodyweight orally daily) for 3 months. Tissue samples from the kidney were taken for determination of the biochemical parameters, lipid peroxidation (LPO), protein carbonyl (PC), reduced glutathione (GSH), total thiol group, antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), in addition to renal mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2), renal levels of inflammatory markers [tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)], and apoptotic markers (BCL2 Associated X (Bax), B-cell lymphoma 2 (Bcl-2), and Bax/Bcl-2 ratio). When compared to the control group, the HFD group’s food consumption, body weight, serum levels of glucose, uric acid, creatinine, LPO, PC, TNF-α, IL-1β, Bax, and the Bax/Bcl-2 ratio all increased significantly. In the kidney sample of HFD-fed rats, there was a downregulation of Nrf2 mRNA expression along with a significant reduction in the enzymatic activity of SOD, CAT, GR, and GPx. Lyc treatment was able to successfully reverse HFD-mediated changes as compared to the HFD group. Consuming lyc helps to prevent fat and renal damage in a positive way.

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“…Studies have shown that apigenin ( 1 ) administration blocks the secretion of pro-inflammatory cytokines and the activation of NF-κB; downregulates the expression of NLRP-3, TLR4, TNF-α, AMPK, and NF-κB; , and decreases the transcriptional activity of NF-κB and the phosphorylation of NF-κB, IκB, IKK, Lyn, Syk, MAPK, ERK, and JNK. , Similarly, luteolin ( 2 ) exerts an anti-inflammatory effect by downregulating the TLR4-mediated NF-κB/NLRP-3 and NF-κB phosphorylation. ,− The protective effects of acteoside ( 27 ) and isoacteoside ( 28 ) are mediated by phosphorylation of IKK, IκBα, NF-κB, and MAPK and the inactivation of TLR4-mediated NF-κB to modulate inflammation. ,− , Additionally, acteoside ( 27 ) restrains the inflammatory responses (TNF-α, IFN-γ, IL-6, and IL-12) by suppressing the JAK/STAT signaling pathway . Furthermore, plantamajoside ( 25 ) has anti-inflammatory properties via inhibition of the phosphorylation of IκBα, JNK, and MAPK, as well as nuclear translocation of NF-κB. , Unexpectedly, on the basis of the MAPK and NF-κB pathway, polysaccharides induce expression of MHC-II and CD86 to promote maturation of dendritic cells (DCs) and then accelerate the secretion of TNF-α and IL-12p70 so it may promote inflammatory effects .…”

Section: Biological Activities and Molecular Pharmacologymentioning

confidence: 99%

“…Studies have shown that apigenin (1) administration blocks the secretion of pro-inflammatory cytokines and the activation of NF-κB; 38 downregulates the expression of NLRP-3, TLR4, TNF-α, AMPK, and NF-κB; 63,64 and decreases the transcriptional activity of NF-κB 65 and the phosphorylation of NF-κB, IκB, IKK, Lyn, Syk, MAPK, ERK, and JNK. 50,66 Similarly, luteolin (2) exerts an anti-inflammatory effect by downregulating the TLR4-mediated NF-κB/NLRP-3 and NF-κB phosphorylation.…”

Section: Action On Cytokinesmentioning

confidence: 99%

Phytochemicals, Biological Activities, Molecular Mechanisms, and Future Prospects of Plantago asiatica L.

Wen

Wei

et al. 2022

J. Agric. Food Chem.

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Plantago asiatica L. has been used as a vegetable and nutritious food in Asia for thousands of years. According to recent phytochemical and pharmacological research, the active compositions of the plant contribute to various health benefits, such as antioxidant, anti-inflammatory, antibacterial, antiviral, and anticancer. This article reviews the 87 components of the plant and their structures, as well as their biological activities and molecular research progress, in detail. This review provides valuable reference material for further study, production, and application of P. asiatica, as well as its components in functional foods and therapeutic agents.

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Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats

Cited by 11 publications

References 80 publications

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Lycopene Effects on Metabolic Syndrome and Kidney Injury in Rats Fed a High-Fat Diet: An Experimental Study

Phytochemicals, Biological Activities, Molecular Mechanisms, and Future Prospects of Plantago asiatica L.

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