Apathy co-occurs with subjective cognitive decline among community-dwelling older adults

Yang, Qing; Wang, Yuxin; Yang, Mengshu; Song, Ge; Cheng, Shiyao; Wang, Chuwen; Zhang, Wenya; Tian, Chong; Mao, Jing

doi:10.1016/j.gerinurse.2022.09.018

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…To control for potential confounding between serum cotinine level and cognitive functioning, after reviewing several related studies ( Peters et al, 2008 ; Pan et al, 2018 ; Ge et al, 2020 ; Yang et al, 2022 ), we included the following covariates in the analysis- age (years), sex (male or female), race/ethnicity (Mexican Americans, other Hispanics, non-Hispanic White, or non-Hispanic Black), education (below high school, high school graduate, or some college or above), depressive symptoms, body mass index (<18.5, 18.5–24.9, 25–29.9, or ≥30 kg/m 2 ), alcohol use (0–1 drink per day, 2 drinks per day, or 3 and more drinks per day), smoking history (former smokers or never smokers), prevalent coronary heart disease (CHD) (yes or no), stroke (yes or no), and systolic blood pressure (mmHg). All the above information was collected from face-to-face interviews or assessed during health exams.…”

Section: Methodsmentioning

confidence: 99%

Higher blood cotinine level is associated with worse cognitive functioning in non-smoking older adults

et al. 2022

Front. Neurosci.

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IntroductionSecondhand smoke (SHS) is common in older adults; however, its cognitive effect is unclear. We aimed to examine the association between serum cotinine level and cognitive functioning among non-smoking older adults.Materials and methodsA total of 2,703 older adults aged 60 and above from the National Health and Nutrition Examination (NHANES) Survey 2011–2014 were included. Serum cotinine level was analyzed in the laboratory. A level ≤10 ng/ml and a response of “no” to the question “Do you currently smoke?” were used to select non-smokers. Cognitive functioning was measured using the Consortium to Establish a Registry for Alzheimer’s disease Word Learning subtest (CERAD-WL) immediate and delayed recall tests, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Multivariable linear regression models were constructed to examine the association between serum cotinine level quartile and test-specific and global cognition z scores adjusting for age, race/ethnicity, education, depressive symptoms, body mass index, alcohol use, smoking history, prevalent coronary heart disease (CHD), stroke, and systolic blood pressure.ResultsAbout half of the participants (mean age 70.5 years) were female (53.6%), non-Hispanic White (48.3%), and completed some college and above (50.2%). Multivariate linear regressions with a reference group being those in the 1st quantile (lowest) showed that participants in the 4th quartile (highest) of serum cotinine level had lower immediate recall [β = −0.16, 95% confidence interval (CI) = −0.29, −0.03], AFT (β = −0.19, 95% CI = −0.33, −0.05), DSST (β = −0.27, 95% CI = −0.39, −0.15), and global cognition (β = −0.26, 95% CI = −0.39, −0.14) z scores. Participants in the 3rd quartile had lower immediate recall (β = −0.16, 95% CI = −0.30, −0.02) and global cognition (β = −0.16, 95% CI = −0.29, −0.02) z scores. Participants in the 2nd quartile had lower delayed recall z scores (β = −0.16, 95% CI = −0.29, −0.02).ConclusionHigher serum cotinine level was associated with worse cognitive functioning in non-smoking older adults. Prevention and reduction of SHS in older adults may help protect their cognitive functioning.

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Section: Methodsmentioning

confidence: 99%

Higher blood cotinine level is associated with worse cognitive functioning in non-smoking older adults

et al. 2022

Front. Neurosci.

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“…Pre-frailty is a latent condition that increases a person’s risk of frailty and typically occurs before clinically identifiable frailty ( 4 ). Existing studies have found that the prevalence of frailty among community-dwelling older individuals 65 and older ranges from 4.0 to 59.1% ( 1 , 5 ). Compared with robust older adults, those with frailty are more likely to fall, be disabled, immobile, require hospitalizations, and have a lower quality of life ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Frailty is associated with worse cognitive functioning in older adults

Song

Yin

et al. 2023

Front. Psychiatry

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IntroductionFrailty and impaired cognitive functioning often co-occur in older adults and are associated with adverse health outcomes. However, their relationship is unclear. This study sought to examine the association of frailty status with cognitive functioning in older adults.MethodThe study population consisted of 2,296 older adults aged ≥60 from the National Health and Nutrition Examination Survey 2011–2014. Frailty status was measured based on the Fried Phenotype and the participants were categorized into three groups- robust, pre-frailty, and frailty. Cognitive functioning was measured using the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subtest (CERAD-WL) immediate and delayed recall tests, the Animal Fluency test (AFT), and the Digit Symbol Substitution Test (DSST). Test-specific and global cognition z-scores were calculated. Multinomial linear regression models were constructed to examine the association between frailty status (reference: robust) and test-specific and global cognition z-scores. Multiple linear regression models were used to examine the relationship between the number of frailty dimensions and test-specific and global cognition z-scores. All models controlled for age, race/ethnicity, education, total cholesterol level, and systolic blood pressure.ResultsAbout half of the participants (median age 68 years) were female (49.9%) and non-Hispanic White (48.7%). A quarter (23.3%) of the participants completed some college and above. Multinominal linear regression showed that compared with participants who were robust, those with frailty had worse DSST [β = –0.234, 95% confidence interval (CI): –0.391, –0.078, P = 0.003] and global cognition z scores (β = –0.129, 95% CI –0.233, –0.025, P = 0.02). Multiple linear regression model showed that the number of frailty dimensions was significantly associated with decreased the DSST (β = –0.065, 95% CI –0.103, –0.026, P = 0.001) and global cognition z-scores (β= –0.034, 95% CI –0.06, –0.009, P = 0.009).ConclusionFrailty is associated with worse processing speed, sustained attention, working memory, and global cognition in older adults. Prevention and treatment of frailty in older adults may help protect their cognitive functioning. Further, clinicians should consider assessing cognitive functioning, especially processing speed, sustained attention, and working memory, among frail older patients, which may allow early identification and interventions of cognitive impairment.

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“…If we compared with robust older adults, those with frailty are more likely to fall, be disabled, immobile, require hospitalizations, and have a lower quality of life [5]. Existing studies have found that the prevalence of frailty among community-dwelling older individuals 65 and older ranges from 4.0 to 59.1% [6,7].…”

Section: Introductionmentioning

confidence: 99%

Cognitive, neuropsychological and biological effects of Oxygen-Ozone Therapy in frailty: a 5-week, randomized, placebo-controlled trial

Scassellati,

Bonvicini,

Ciani

et al. 2024

Preprint

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As the world’s population age, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. This pilot study aims to investigate the potential cognitive and neuropsychological effects of a 5-week treatment with a therapy based on the regenerative properties of ozone (O3) in a cohort of patients stratified according to CF. We also study the potential effects of O3 on blood-based biomarkers indicative of specific biological systems that may be altered in CF. Seventy-five older persons have been recruited and randomly assigned to receive the active treatment (150cc of oxygen-O2-O3 mixture at the concentration of 30ug of O3 per cc of O2) or O2, or the placebo (air) for 5 weeks. The primary endpoint is a change in the scores of clinical scales from baseline (T0) to weeks 3 (T3), 9 (T9), 15 (T15) after treatment. The secondary endpoint is a change in biomarkers levels resulting from transcriptomics, proteomics and metabolomic patterns at the same times. This study will evaluate whether an intervention with the O2-O3 therapy could have potential cognitive, neuropsychological and biological effects on CF.

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Apathy co-occurs with subjective cognitive decline among community-dwelling older adults

Cited by 4 publications

References 34 publications

Higher blood cotinine level is associated with worse cognitive functioning in non-smoking older adults

Higher blood cotinine level is associated with worse cognitive functioning in non-smoking older adults

Frailty is associated with worse cognitive functioning in older adults

Cognitive, neuropsychological and biological effects of Oxygen-Ozone Therapy in frailty: a 5-week, randomized, placebo-controlled trial

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