Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

Factors Associated with Blood Pressure Control in Hypertensive Patients with Coronary Heart Disease: Evidence from the Chinese Cholesterol Education Program

“…In our present study, we found a significant association of uncontrolled BP with the presence of obesity, SAP and family history of DM, which were consistent with other previous publications [16], [17]. Cardiac autonomic dysfunction may explain poor blood pressure control in overweight and obese hypertensive patients with CHD [16].Actually, these metabolism-related disorders, mainly with elevated plasma glucose and cholesterol, would have a considerable impact not only on the atherosclerosis, such as in patients with CHD, but also on arteriolosclerosis, a condition with increased arterial stiffness.…”

Does an increase in estimated pulse wave velocity increase the incidence of hypertension?

“…This suggests that elevated ePWV is a risk factor for elevated SBP and DBP, and is a potential predictor of hypertension development. Our results are consistent with previous studies on arterial stiffness and the risk of hypertension [8,9,18,19]. Bernhard et al [8] measured cfPWV in 3539 individuals multiple times.…”

“…Our results are consistent with previous studies on arterial stiffness and the risk of hypertension [8,9,18,19]. Bernhard et al [8] measured cfPWV in 3539 individuals multiple times. They found that for every 1 standard deviation increase in cfPWV, SBP increased by 1.5 mmHg, and the risk of hypertension also increased (odds ratio: 1.3) [8].…”

Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study

“…Previously, one small study reported no association between cfPWV progression and HOMA ( 19 ), but HbA 1c has been associated with progressive carotid artery stiffening in the Atherosclerosis Risk in Communities (ARIC) Study ( 37 ), although, unfortunately, cfPWV was not assessed. In the current study, cfPWV increased by ∼0.7 m/s, which is consistent with previous longitudinal studies, which have reported increases of between 0.2 and 0.6 m/s per 5 years in participants aged ∼60 years ( 18 , 20 , 24 ). Moreover, modest differences of 0.07% in HbA 1c or 0.67 units in HOMA-IR were associated with an ∼0.1 m/s greater increase in cfPWV over 5 years, equating to ∼12–14% of the overall change in stiffness.…”