Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus

Ersoy, Murat; Duru, Nilgün Selçuk; Elevli, Murat; Ersoy, Özlem; Çivilibal, Mahmut

doi:10.5812/ijp.368

Cited by 18 publications

(30 citation statements)

References 20 publications

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“…In this study, the STZ injection significantly increased the thickness of tunica media and aortic wall. In human studies, tunica media thickness of aorta increased significantly in diabetes compared with that of healthy people [45,46]. The present study showed that quercetin administration ameliorated the thickness of aortic wall and organization of elastic fibrils.…”

Section: Discussionsupporting

confidence: 61%

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

et al. 2015

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Background: Diabetes mellitus (DM) is a chronic endocrine-metabolic disorder associated with endothelial dysfunction. Hyperglycemia, dyslipidemia and abnormal nitric oxide-mediated vasodilatation are the major causal factors in the development of endothelial dysfunction in DM. The prevention of endothelial dysfunction may be a first target against the appearance of atherosclerosis and cardiovascular diseases. We have investigated the synergistic protective effects of quercetin administration and moderate exercise training on thoracic aorta injuries induced by diabetes. Methods: Diabetic rats that performed exercise training were subjected to a swimming training program (1 h/day, 5 days/week, 4 weeks). The diabetic rats received quercetin (30 mg/kg body weight/day) for 4 weeks. At the end of the study, the thoracic aorta was isolated and divided into two parts; one part was immersed in 10% formalin for histopathological evaluations and the other was frozen for the assessment of oxidative stress markers (malondialdehyde, MDA and protein carbonyls groups, PC), the activity of antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT), nitrite plus nitrate (NOx) production and inducible nitric oxide synthase (iNOS) protein expression. Results: Diabetic rats showed significantly increased MDA and PC levels, NOx production and iNOS expression and a reduction of SOD and CAT activity in aortic tissues. A decrease in the levels of oxidative stress markers, NOx production and iNOS expression associated with elevated activity of antioxidant enzymes in the aortic tissue were observed in quercetin-treated diabetic trained rats. Conclusions: These findings suggest that quercetin administration in association with moderate exercise training reduces vascular complications and tissue injuries induced by diabetes in rat aorta by decreasing oxidative stress and restoring NO bioavailability.

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Section: Discussionsupporting

confidence: 61%

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

et al. 2015

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“…Ulutaş et al (42) also reported a positive correlation between MPV level and HbA1c level, which is following our results. Hekimsoy et al (43), have shown the opposite, while Ersoy et al (44), reported similar MPV values in children diagnosed with T1DM to those in a control group (8.74 ± 0.96 and 8.49 ± 0.66, respectively). These different results in platelet count could be explained by their dependency on several variables, such as mean platelet survival, platelet production rate, and turnover rate in diabetes mellitus.…”

Section: Spearman Correlation Analysismentioning

confidence: 89%

“…Type 1 diabetes mellitus (T1DM) is one of the most common endocrinological disorders in children and adolescents (1,2). It is caused by various environmental factors interacting with an underlying genetic predisposition resulting in autoimmune destruction of pancreatic beta cells (3,4). The onset of type 1 diabetes mellitus occurs early in life and children affected are at great risk of developing microvascular and macrovascular complications and cardiovascular disease later as a complication of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of hematologic indices and their correlation to hemoglobin A1c among Bosnian children with type 1 diabetes mellitus and their healthy peers

Tihić-Kapidžić¹,

Čaušević²,

Fočo-Solak³

et al. 2021

J Med Biochemistry

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Background: Altered level of many hematological parameters have been directly associated with diabetes in adults, while studies on children with type 1 diabetes mellitus are lacking. The aim of this study was to determine hematological indices in diabetic Bosnian children in comparison to healthy controls as well as to correlate their levels to blood glucose and hemoglobin A1c. Methods: 100 healthy and 100 children with type 1 diabetes mellituss (age 1-18 years) were included in this study. Complete Blood Count, Hemoglobin A1c and glucose were tested. Results were analysed by IBM SPSS Statistics version 23. Results: Significant differences (p<0.05) between healthy and diabetic children were found in HbA1c, glucose, Mean Platelet Volume, number of white blood cells and erythrocytes, hematocrit, hemoglobin and MCH values. No gender differences or significant age differences were seen for hemoglobin, hematocrit and MCV, while platelets, MPV and MCH differed by age only in healthy children. When diabetic children were classified according to HbA1c levels, significant differences were seen for erythrocyte count and hematocrit value (p=0.013 and 0.019 respectively). Number of erythrocytes and white blood cells correlated significantly with HbA1c (p=0.037 and 0.027 respectively). Conclusion: Lower levels of erythrocytes, hematocrit and hemoglobin in diabetic compared to healthy children indicate possible development of anemia, while higher MCV, MCH and MPV values indicate alteration in erythrocyte morphology. Hematological indices could be useful inexpensive tool in diagnosis and follow up of type 1 diabetes in children.

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“…Various different studies have thus suggested that platelets can be used as a marker for predicting an increase in the risk of the micro-and macrovascular complications of diabetes [13][14][15]. However, Ersoy et al [16] reported similar MPV values in children diagnosed with T1DM to those in a control group (8.74 ± 0.96 and 8.49 ± 0.66, respectively), although correlation was determined between intima-media thickness and MPV values. Similarly, in our study, we determined no statistically significant difference in MPV values between children with T1DM and the control group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

Korkmaz¹

2018

J Endocrinol Metab

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Background: The purpose of this study was to assess platelet morphological parameters in children and adolescents with type 1 diabetes mellitus (T1DM) and to determine the factors affecting those parameters. Methods: A total of 80 children with type 1 diabetes mellitus and 80 healthy control subjects were included in this study. All subjects' platelet parameters including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) levels were measured. Age at diagnosis, duration of diabetes, and hemoglobin A1c (HbA1c) levels of patients with T1DM were also recorded. Results: There was no significant difference in PLT, MPV, PDW and PCT values between patients and controls (P > 0.05). PCT and PLT values were higher in patients with poor metabolic control compared to the other cases (P = 0.002, P = 0.005). Positive correlation was found between HbA1c and PCT (r = 0.28, P = 0.01). There was no correlation between HbA1c and MPV, PDW and PLT. Conclusions: Indices of platelet morphology such as PCT, PLT, PDW and MPV were similar in children with T1DM and in healthy controls. However, an increase in PCT values in poor glycemic control group and a significant positive correlation between PCT and HbA1c were observed, suggesting that PCT levels may be an early marker of vascular complication.

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Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus

Cited by 18 publications

References 20 publications

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

Assessment of hematologic indices and their correlation to hemoglobin A1c among Bosnian children with type 1 diabetes mellitus and their healthy peers

Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

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