2009
DOI: 10.1007/s00259-008-1047-z
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Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification

Abstract: Aortic inflammation, assessed by hybrid FDG-PET/CT imaging, is associated with an enhanced aortic stiffness, in addition to the concurrent impact of calcifications.

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Cited by 49 publications
(40 citation statements)
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“…Nevertheless, in our multivariable model, PWV was the strongest independent determinant of FDG uptake even after adjustment for HbA 1c . The association that we found between FDG uptake and PWV and cSBP has also been observed predominantly in patients without diabetes (23). This study of 26 patients demonstrated that SUV max was significantly associated with central aortic PWV (R 2 = 0.16, P = 0.004).…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…Nevertheless, in our multivariable model, PWV was the strongest independent determinant of FDG uptake even after adjustment for HbA 1c . The association that we found between FDG uptake and PWV and cSBP has also been observed predominantly in patients without diabetes (23). This study of 26 patients demonstrated that SUV max was significantly associated with central aortic PWV (R 2 = 0.16, P = 0.004).…”
Section: Discussionsupporting
confidence: 75%
“…Fourth, we did not include a group without diabetes. Therefore, we cannot conclude that the relationship between FDG uptake and aortic stiffness occurs exclusively in diabetes, and it may also be found in other populations (without diabetes) with an increased risk of developing atherosclerosis (23). Fifth, the optimal acquisition circulation time for FDG-PET/CT imaging to assess vascular inflammation is not well known.…”
Section: Discussionmentioning
confidence: 91%
“…8 In humans, hybrid fluorodeoxyglucose-positron emission tomography/ computed tomography imaging demonstrates stiffness to be associated with both calcification and inflammation. 9 Imaging modalities, such as computed tomography, do not reveal microcalcification, but it is likely that this is associated with the macrocalcification seen in subjects with increased arterial stiffness (Figure). It is less certain whether systemic inflammation arising from a stimulus other than atherosclerosis promotes calcification.…”
mentioning
confidence: 99%
“…This is in addition to and independent of, the changes that occur due to risk factors and the atherosclerotic process [23]. Furthermore, in certain diseases, and especially in the elderly, an inflammatory process may be present in the wall of the aorta that also contributes to its structural and functional abnormalities [24,25,26]. All these alterations of the aortic wall over time can eventually lead to aortic dilatation, dissection, and rupture (Fig.…”
Section: Factors Determining Aortic Dilatation and Rupturementioning
confidence: 99%