volume 93, issue 0, P2-P-176 2020
DOI: 10.1254/jpssuppl.93.0_2-p-176
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Abstract: Chronic kidney disease (CKD) is a risk factor for cerebrovascular diseases, and patients with CKD are susceptible to ischemic and hemorrhagic stroke. Many CKD patients complain of anxiety and other psychiatric symptoms; however, involvement in the mechanism of brain disfunction associated with decreased renal function is unknown. In this study, we analyzed psychiatric symptoms and the changes in the brain of 5/6-nephrectomized (CKD) mice, focusing on redox signaling pathways. In the dark/light box test and the…

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