Anxiety independently contributes to elevated inflammation in humans with obesity

Pierce, Gary L.; Kalil, Graziela Z; Ajibewa, Tiwaloluwa A.; Holwerda, Seth W.; Persons, Jane E.; Moser, David J.; Fiedorowicz, Jess G.

doi:10.1002/oby.21698

Cited by 33 publications

(33 citation statements)

References 20 publications

(36 reference statements)

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“… 7 – 9 , 40 Previous studies reported that anxiety symptoms were associated with increased levels of TNF-α, IL-6 and CRP. 8 , 9 , 41 Duivis et al also observed elevated serum CRP levels in a male population after adjusting for sociodemographic and lifestyle-related confounding factors in a large adult sample. 40 These previous results are inconsistent with our finding that the anxiety score was not associated with inflammation levels in a multivariate and stratified analysis.…”

Section: Discussionmentioning

confidence: 92%

<p>Depression and Perceived Stress, but Not Anxiety, are Associated with Elevated Inflammation in an Obese Adult Population</p>

Zou¹,

Miao²,

Chen³

2020

RMHP

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Background Anxiety, depression and perceived stress are risk factors for adverse health problems. Inflammation participates in the development of chronic diseases such as psychiatric disorders. This study explored the relationships between inflammatory biomarkers and depression, anxiety and perceived stress in an obese adult population. Methods The relationships between psychological scores and inflammatory markers were analyzed. Results A higher BMI was not correlated with a higher anxiety score (P=0.152); however, BMI was positively associated with a higher depression score (P<0.001) and a higher perceived stress score (P<0.001). Multivariate linear regression analysis revealed that in participants with BMI≥30 and 25≤BMI<30, depression and perceived stress were significantly and independently associated with ICAM-1, E-selectin and CRP, but these associations were not observed in participants with BMI<25. The anxiety score was not associated with any inflammatory marker in any group of subjects, as determined by multivariate analysis. Conclusion Depression and perceived stress were strongly associated with increased serum levels of pro-inflammatory markers, including ICAM-1, E-selectin and CRP, among a general obese population from the United States. These results further suggest that depression and perceived stress might also be chronic systemic inflammatory diseases.

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Section: Discussionmentioning

confidence: 92%

<p>Depression and Perceived Stress, but Not Anxiety, are Associated with Elevated Inflammation in an Obese Adult Population</p>

Zou¹,

Miao²,

Chen³

2020

RMHP

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“…In addition, the present study found that obese patients had significantly more symptoms of depression than did underweight, eutrophic and overweight patients. The literature suggests that excess body weight is highly-associated with the appearance of anxiety and depression symptoms (41,42) . A recent study in Poland with patients with IBD also found significant results regarding overweight and higher levels of depressive symptoms (43) .…”

Section: Discussionmentioning

confidence: 99%

Symptoms of Anxiety and Depression, and Quality of Life of Patients With Crohn’s Disease

Tomazoni

Benvegnú

2018

Arq. Gastroenterol.

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-Background -Crohn's disease is an idiopathic chronic inflammatory disease. It is classified as an inflammatory bowel disease. Crohn's disease can change patient quality of life, especially during flares. Crohn's disease has been associated with symptoms of anxiety and depression, because the clinical symptoms have a high impact on quality of life. Objective -To investigate the prevalence of symptoms of anxiety and depression in Brazilian patients diagnosed with Crohn's disease, as well as their quality of life. Methods -A total of 110 Brazilian patients aged 21-59 years, both genders, with Crohn's disease were included. The data were collected through questionnaires. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depression symptoms. Quality of life was evaluated using the Inflammatory Bowel Disease Questionnaire. Data were analyzed by ANOVA, followed by the Duncan post-hoc test and the multiple linear regression test. Results -Of the total, 61.7% of participants reported symptoms of anxiety or depression or both. Regarding quality of life, the majority (43.6%) were classified as "regular" and the minority (3.6%) as "excellent". Multiple linear regression showed that worse quality of life correlated with greater presence of anxiety and depression symptoms (<0.001).Conclusion -Crohn's disease has considerable impact on quality of life and contributes to the appearance of anxiety and/or depression symptoms. HEADINGS -Crohn disease. Quality of life. Anxiety. Depression.

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“…The cause of this phenomenon is seen in the inflammatory system that is modulated by obesity [26]. It was found that in a group of 10,348 women, BMI was positively correlated with mild to moderate depressive disorders and also with high levels of depression.…”

Section: Discussionmentioning

confidence: 99%

“…It includes low self-esteem, the feeling of being stigmatised, or disturbances in employment and relationships [25]. Likewise, the deterioration of the disease, which results from the elevated inflammatory response, related to both anxiety and depression, may account for the poorer outcome of quality of life questionnaires [26].…”

Section: Discussionmentioning

confidence: 99%

Depressive and anxiety symptoms among patients with inflammatory bowel diseases

Bielińska

Liebert

Lesiewska

et al. 2017

Medical Research Journal

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Depressive and anxiety symptoms among patients with inflammatory bowel diseases ABSTRACT Introduction. This study was conducted on a population of patients with inflammatory bowel disease (IBD) and was based on an assessment of the prevalence and severity of depression and anxiety symptoms in various clinical aspects. The psychological features of IBD patients are very important in the perception of symptoms, but crucial as triggers of IBD or as a releasing factor for IBD symptoms recurrence.Methods. The study included 130 patients with IBD, including 68 with Crohn's disease (CD) and 62 with ulcerative colitis (UC). The severity of anxiety and depression symptoms were examined by the Hospital Anxiety and Depression Scale (HADS). Patients were also subjected to assessment of anthropometric attributes, clinical factors, quality of life, and symptoms of the disease, with dedicated clinical scales.Results. The occurrence of significant symptoms of anxiety was estimated at 45.5% in patients with CD and 30.5% in the UC patients. Significant depressive symptoms related to 20.5% of people with CD and 17.5% of patients with UC. The parameters of anxiety and depression showed significant associations with parameters of quality of life, BMI, and the scales describing the exacerbation of the diseases.Conclusions. The analyses did not reveal significant differences in the severity and prevalence of symptoms of anxiety and depression in subgroups with IBD. The expansion of relevant symptoms of anxiety and depression in this population was greater than in the general population. In addition, there was a significant correlation between parameters of HADS and clinical factors.

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Anxiety independently contributes to elevated inflammation in humans with obesity

Cited by 33 publications

References 20 publications

<p>Depression and Perceived Stress, but Not Anxiety, are Associated with Elevated Inflammation in an Obese Adult Population</p>

<p>Depression and Perceived Stress, but Not Anxiety, are Associated with Elevated Inflammation in an Obese Adult Population</p>

Symptoms of Anxiety and Depression, and Quality of Life of Patients With Crohn’s Disease

Depressive and anxiety symptoms among patients with inflammatory bowel diseases

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