Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes

Fc, Mello; Ca, Fernandes; Gomes, Saint Clair

doi:10.1590/s0074-02762012000300005

Cited by 13 publications

(14 citation statements)

References 56 publications

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“…Based on sequence divergence in the entire genome exceeding 8% or in S gene exceeding 4%, HBV is currently classified into eight genotypes, designated A to H. In addition, most of these genotypes have been subclassified recently into subgenotypes with distinct virological and epidemiological properties [2]–[5]. Research on HBV genotypes during the last decade has associated the HBV genotypes significantly with the severity of liver disease, clinical outcomes and the response to antiviral therapies [6]–[8]. It has been documented that HBV genotypes or subgenotypes vary in geographical distribution.…”

Section: Introductionmentioning

confidence: 99%

A Novel Complex A/C/G Intergenotypic Recombinant of Hepatitis B Virus Isolated in Southern China

Liu

et al. 2014

PLoS ONE

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Hepatitis B virus (HBV) genotypes and subgenotypes may vary in geographical distribution and virological features. Previous investigations, including ours, showed that HBV genotypes B and C were respectively predominant in South and North China, while genotypes A and D were infrequently detected and genotype G was not found. In this study, a novel A/C/G intergenotype was identified in patients with chronic HBV infection in Guilin, a city in southern China. Initial phylogenetic analysis based on the S gene suggested the HBV recombinant to be genotype G. However, extended genotyping based on the entire HBV genome indicated it to be an A/C/G intergenotype with a closer relation to genotype C. Breakpoint analysis using the SIMPLOT program revealed that the recombinant had a recombination with a arrangement of genotypes A, G, A and C fragments. Compared with the HBV recombinants harboring one or two genotype G fragments found in Asian countries, this Guilin recombinant was highly similar to the Vietnam (98–99%) and Long An recombinants (96–99%), but had a relatively low similarity to the Thailand one (89%). Unlike those with the typical genotype G of HBV, the patients with the Guilin recombinant were seropositive for HBeAg. Moreover, a relatively high HBV DNA viral load (>2×106 IU/ml) was detected in the patients, and the analysis of viral replication capacity showed that the Guilin recombinant strains had a competent replication capacity similar to genotypes B and C strains. These findings can aid in not only the clarification of the phylogenetic origin of the HBV recombinants with the genotype G fragment found in Asian countries, but also the understanding of the virological properties of these complicated HBV recombinants.

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Section: Introductionmentioning

confidence: 99%

A Novel Complex A/C/G Intergenotypic Recombinant of Hepatitis B Virus Isolated in Southern China

Liu

et al. 2014

PLoS ONE

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“…The cornerstone objective of antiviral therapy in HBV infection is to permanently suppress viral replication in a sustained manner, thus preventing disease progression, inhibiting HCC development, and prolonging patient survival (11) (20) . For the whole cohort, tenofovir monotherapy was the drug of choice for treating HBV.…”

Section: Discussionmentioning

confidence: 99%

“…However, an important factor in this study was the large number of patients with high alcohol consumption that might have affected the serum ALT results. Few studies have investigated antiviral therapy in Brazil and most of them have highlighted gene mutations and HBV genotypes (11) (20) (21) . In line with our results, tenofovir was the most prescribed drug for individuals with chronic HBV in the neighboring state of Parana (21) ; however, lamivudine monotherapy was the chosen treatment in 66.7% of patients in a cross-sectional study of patients chronically infected with HIV in different Brazilian sites (11) .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have investigated antiviral therapy in Brazil and most of them have highlighted gene mutations and HBV genotypes (11) (20) (21) . In line with our results, tenofovir was the most prescribed drug for individuals with chronic HBV in the neighboring state of Parana (21) ; however, lamivudine monotherapy was the chosen treatment in 66.7% of patients in a cross-sectional study of patients chronically infected with HIV in different Brazilian sites (11) . In an American community-based cohort, antiviral therapy and viral suppression were the most effective ways to reduce the incidence of HBV-induced HCC; this fi nding was confi rmed in Asian and Europeans studies (22) .…”

Section: Discussionmentioning

confidence: 99%

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Clinical, demographic, and epidemiologic characteristics of hepatitis B virus-infected patients at a tertiary public hospital in Presidente Prudente, State of São Paulo, Brazil

Prestes-Carneiro

Vieira

Isaac

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…3,[5][6][7][8][9] No Brasil a hepatite B apresenta indicadores epidemiológicos que variam de acordo com a região, apresentando uma prevalência relativamente baixa no Sul do país, contrastando com os indicadores da região Norte, principalmente na Amazônia ocidental, onde estudos identificaram formas graves da doença, em localidades com elevada prevalência de infecção por VHB e VHD. 3,10,11 O VHB e o VHD são transmitidos por via parenteral e capazes de levar ao desenvolvimento de doença hepática crônica com muitas complicações evolutivas, tais como quadros de poliarterite, glomerulonefrite, polimialgia reumática, crioglobulinemia, dentre outras, com destaque para a cirrose hepática e o carcinoma hepatocelular (CHC).…”

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Hepatite B e a superinfecção por vírus D em pacientes crônicos na Amazônia ocidental brasileira

Oliveira

Valle

Silva

et al. 2015

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. Method:Descriptive study based on secondary data from medical records of 208 patients. These patients were divided into two (2) groups (HBV and HBV+HDV), followed in Hepatology Clinic from Sanitary Dermatology Hospital in Cruzeiro do Sul city, Acre state, a regional reference healthcenter. Results: 42.8% -of the 208 records analyzedhave presented HBV infection, and 57.2% were diagnosed with coinfection, ie. HBV+HDV, associated hepatitis viruses infection. Both patients group were predominantly male (67.4% = HBV, and 67.2% = HBV+HDV), aged between 12 and 31 years old. Regarding the analysis of clinical, serological, biochemical and hematological, an overview have showed that, the group with associated HBV+HDV infection presented a poorer prognosis compared to the group with HBV monoinfection. Conclusion: It is possible to assert that superinfection by HDV, in the western Brazilian Amazon, is a serious health problem. It is necessary to carry out studies, especially with clinical approach, concerning chronically ill patients. RESUMO ABSTRACT

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Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes

Cited by 13 publications

References 56 publications

A Novel Complex A/C/G Intergenotypic Recombinant of Hepatitis B Virus Isolated in Southern China

A Novel Complex A/C/G Intergenotypic Recombinant of Hepatitis B Virus Isolated in Southern China

Clinical, demographic, and epidemiologic characteristics of hepatitis B virus-infected patients at a tertiary public hospital in Presidente Prudente, State of São Paulo, Brazil

Hepatite B e a superinfecção por vírus D em pacientes crônicos na Amazônia ocidental brasileira

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