volume 67, issue 1, P332-339 1993
DOI: 10.1128/jvi.67.1.332-339.1993
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F Lehmann-Grube, J Löhler, O Utermöhlen, C Gegin

Abstract: Mice infected intracerebrally with lymphocytic choriomeningitis virus (LCM virus) develop a characteristic central nervous system disease and usually die. If the intravenous or intraperitoneal route is used, the infection leads to less severe clinical signs and the virus is eliminated. Illness and virus clearance are immunological phenomena, which are assumed to be caused exclusively by CD8+ T lymphocytes. In contrast, of the two phases of a delayed-type hypersensitivity reaction caused by inoculation of the v…

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