Antiviral effects of probiotic metabolites on COVID-19

Abstract

SARS coronavirus (COVID-19) is a real health challenge of the 21st century for scientists, health workers, politicians, and all humans that has severe cause epidemic worldwide. The virus exerts its pathogenic activity through by mechanism and gains the entry via spike proteins (S) and Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins on host cells. The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp). Docking studies were designed in order to obtain the binding energies for Plantaricin metabolites. The binding energies for Plantaricin W were À14.64, À11.1 and À12.68 for polymerase, RBD and ACE2 respectively comparatively very high with other compounds. Plantaricin W, D, and JLA-9 were able to block the residues (THR556, ALA558) surrounding the deep grove catalytic site (VAL557) of RdRp making them more therapeutically active for COVID-19. Molecular dynamics studies further strengthen stability of the complexes of plantaricin w and SARS-CoV-2 RdRp enzyme, RBD of spike protein, and human ACE2 receptor. The present study present multi-way options either by blocking RBD on S proteins or interaction of S protein with ACE2 receptor proteins or inhibiting RdRp to counter any effect of COVID-19 by Plantaricin molecules paving a way that can be useful in the treatment of COVID-19 until some better option will be available.

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

“… 1 Targeting the gut–lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection Review [ 157 ] 2 Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives Review [ 158 ] 3 Traditional Chinese medicine for COVID-19 treatment Review [ 159 ] 4 Gut microbiota and Covid-19- possible link and implications Review [ 160 ] 5 Probiotics and COVID-19 : one size does not fit all Review [ 161 ] 6 Potential Effects Immunomodulators on Probiotics in COVID-19 Preventing Infection in the Future. A Narrative Review Review [ 162 ] 7 The small intestine, an underestimated site of SARS-CoV-2 infection: from Red Queen effect to probiotics Review [ 60 ] 8 Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles Review [ 163 ] 9 Antiviral effects of probiotic metabolites on COVID-19 Express Communication [ 164 ] 10 Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic Review [ 165 ] 11...…”

The First Case of COVID-19 in South Kalimantan

“…[21][22][23][24][25] Most treatments for COVID- 19 as zinc administration, because probiotics can block or inactivate RdRp so it will prevent virus replication. [26][27][28][29][30][31] Since COVID-19 was a novel disease, there was not any patent guideline. When we treated our first patient, most of our drugs was based on newly released journals.…”

Immunomodulatory effects of probiotics

“…Большое количество публикаций на сегодняшний день демонстрирует, что пероральные пробиотические штаммы могут снизить частоту и тяжесть вирусных инфекций дыхательных путей. В то время, когда врачи используют препараты, у которых мало данных по борьбе с COVID-19, пробиотические штаммы, задокументированные для противовирусной и респираторной активности, должны стать частью арсенала, чтобы снизить бремя и тяжесть этой инфекции [96][97][98][99][100][101][102][103][104][105]. Сегодня на пробиотическом отечественном рынке серьезную нишу занимает «семейство» из Великобритании: Бак-Сет ® Форте, Бак-Сет ® Беби и Бак-Сет ® Колд/Флю.…”