Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections

Rajtar, Barbara; Skalicka-Woźniak, Krystyna; Świątek, Łukasz; Boguszewska, Anastazja; Polz‐Dacewicz, Małgorzata

doi:10.1016/j.fct.2017.05.011

Cited by 48 publications

(24 citation statements)

References 26 publications

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“…The extract resulted in a decrease in the titer of the virus concerning the control of the virus. The findings demonstrate that coumarins of A. archangelica may be an excellent material for the formation of an alternative natural anti‐HSV‐1 compound (Rajtar et al, 2017).…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 86%

Medicinal plants: Treasure for antiviral drug discovery

Ali

Sheikh

Rather

et al. 2021

Phytotherapy Research

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The pandemic of viral diseases like novel coronavirus (2019‐nCoV) prompted the scientific world to examine antiviral bioactive compounds rather than nucleic acid analogous, protease inhibitors, or other toxic synthetic molecules. The emerging viral infections significantly associated with 2019‐nCoV have challenged humanity's survival. Further, there is a constant emergence of new resistant viral strains that demand novel antiviral agents with fewer side effects and cell toxicity. Despite significant progress made in immunization and regenerative medicine, numerous viruses still lack prophylactic vaccines and specific antiviral treatments that are so often influenced by the generation of viral escape mutants. Of importance, medicinal herbs offer a wide variety of therapeutic antiviral chemotypes that can inhibit viral replication by preventing viral adsorption, adhering to cell receptors, inhibiting virus penetration in the host cell, and competing for pathways of activation of intracellular signals. The present review will comprehensively summarize the promising antiviral activities of medicinal plants and their bioactive molecules. Furthermore, it will elucidate their mechanism of action and possible implications in the treatment/prevention of viral diseases even when their mechanism of action is not fully understood, which could serve as the base for the future development of novel or complementary antiviral treatments.

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Section: Antiviral Molecules Of Plant Originmentioning

confidence: 86%

Medicinal plants: Treasure for antiviral drug discovery

Ali

Sheikh

Rather

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The substance cytotoxicity was evaluated with the MTT formazan test (Rajtar et al 2017). On the basis of cell measurement, the IC 50 of the testing substance-the concentration which caused 50% reduction of the cell activity compared to the control, was determined.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

et al. 2021

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This article is a part of a scientific project focused on obtaining a new type of composite materials that are characterized by singlet oxygen generation upon irradiation with red light, which can be used as antibacterial agents. The composite material is nanoscale graphite oxide (GO) particles covalently bonded to an axially substituted zirconium phthalocyanine complex. For this purpose, two phthalocyanine zirconium complexes, axially mono-substituted with 4-aminosalicylic or 4-aminophthalic acids, were prepared and measured in terms of structure, morphology, and spectroscopic properties. The zirconium phthalocyanines are photosensitizers, and the axial ligands are bridging links connecting the complexes to the GO carrier (due to their terminal amino groups and carboxyl groups, respectively). The axial ligand in zirconium phthalocyanine complexes has a strong influence on the stability and optical properties of composite materials and, consequently, on reactive oxygen species (ROS) generation. In this paper, the effect of composite components (4-aminophthalato or 4-aminosalicylato substituted zirconium phthalocyanine complex as a photosensitizer and graphite oxide as a carrier and modulator of the action of active components) on ROS generation for potential antibacterial use is discussed.

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“…It has been reported that a cranberry extract known as Oximacro and its purified constituent proanthocyanidins can inhibit HSV-1 and HSV-2 replication in vitro and prevent the virus adsorption by targeting the viral envelop glycoprotein gD and gB (Terlizzi et al, 2016). The dichloromethane extract from Angelica archangelica L. fruit is a potential antiviral against HSV-1 by inhibiting viral replication (Rajtar et al, 2017). Fig.…”

Section: • Inhibition Of Virus Replicationmentioning

confidence: 99%