Antiviral activity of the sea cucumber tegument extract (<i>Pattalus mollis</i>) on human rotavirus A (RVA)

García-Candela, Enrique; Pariona-Velarde, Daniel; Mondragón-Martínez, Aarón; Chumpitaz-Cerrate, Víctor

doi:10.1080/14786419.2019.1611807

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Garlic aqueous extract potentially inhibits PRV in MA104 cells, possibly by blocking the ERK/MAPK signaling pathway (EC 50 = 0.03 mg/ mL) (161, 162). The sea cucumber tegument extract (Pattalus mollis) has a significant inhibitory effect on HRV and acts before the virus enters the cells (CC 50 = 27,042.10 mg/mL, IC 50 = 64.29 mg/ mL) (163).…”

Section: Chinese Medicine and Natural Compoundsmentioning

confidence: 99%

Advances in the development of antivirals for rotavirus infection

et al. 2023

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Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review discusses the viral replication cycle in detail and outlines possible therapeutic approaches including immunotherapy, probiotic-assisted therapy, anti-enteric secretory drugs, Chinese medicine, and natural compounds. We present the latest advances in the field of rotavirus antivirals and highlights the potential use of Chinese medicine and natural compounds as therapeutic agents. This review provides an important reference for rotavirus prevention and treatment.

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Section: Chinese Medicine and Natural Compoundsmentioning

confidence: 99%

Advances in the development of antivirals for rotavirus infection

et al. 2023

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“…The antiviral drug class consists of medicines Experiments with some virus-infected cells have demonstrated that sea cucumbers possess promising antiviral properties. Previously, Garcia-Candela et al (2021) reported that an aqueous extract of Patallus mollis sea cucumber exerts an antiviral effect on human rotavirus A by inhibiting 99% of the virus during two distinct phases of the virus: absorption and viral inactivation phase. Sulfated fucan and fucosylated chondroitin sulfate from the sea cucumber I. badionotus exhibited antiviral properties against adenovirus and human cytomegalovirus and it is accompanied by the sulfation content, negative charge density, and conformational shapes (Zoepfl et al, 2021).…”

Section: Antiviral Activities Reported From Sea Cucumbersmentioning

confidence: 99%

Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Sanjeewa¹,

Herath²

2023

Fish Aquat Sci

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The bioactive secondary metabolites produced by sea cucumbers are very diverse with differences in composition, linkages, molecular weight, and various functional properties. Due to their physicochemical properties, these bioactive molecules in sea cucumbers have found applications in various market segments such as functional foods and cosmetics. Sea cucumber side dishes are a prominent food item in traditional cuisine in East Asian countries such as South Korea, China, and Japan. In addition, many studies have reported that the consumption of sea cucumbers can reduce the risk of cardiovascular disease, the pathogenesis of cancer cells, chronic inflammatory diseases, etc. In particular, many studies have recently reported the potential of sea cucumbers to develop functional products to reduce inflammation, oxidative stress, diabetes, and cancer. Additionally, these bioactive properties associated with sea cucumbers make them ideal compounds for use as functional ingredients in functional food products. However, no report has yet reviewed the properties of sea cucumbers related to functional foods. Therefore, in this review, the primary focus is given to collecting published scientific data (from 2019 to 2023) on the bioactive properties of sea cucumbers relevant to the functional food industry.

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“…A synthetic derivative of antimicrobial peptide Holothuroidea 2 from Mediterranean Sea cucumber ( Holothuria tubulosa ) has been considered to have an inhibitory effect on Listeria monocytogenes ( 5 ). Very recently, it was found that the sea cucumber tegument extract inhibits 99% of the virus during the absorption and viral inactivation phase ( 6 ). Anti-cancer effect is the most attractive function of the sea cucumber active substances.…”

Section: Introductionmentioning

confidence: 99%

Sea Cucumber Intestinal Peptide Induces the Apoptosis of MCF-7 Cells by Inhibiting PI3K/AKT Pathway

et al. 2021

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Sea cucumbers are one of many marine echinoderm animals that contain valuable nutrients and medicinal compounds. The bioactive substances in sea cucumbers make them have promising biological and pharmacological properties, including antioxidant, anti-bacterial, and anti-tumor effects. In this study, sea cucumber intestinal peptide (SCIP) is a small molecular oligopeptide (<1,000 Da) extracted from sea cucumber intestines hydrolyzed by alkaline protease. The analysis of amino acid composition showed that hydrophobic amino acids and branched-chain amino acids were rich in SCIP. Nowadays, although increasing studies have revealed the biological functions of the sea cucumber active substances, there are few studies on the function of SCIP. Furthermore, due to the anti-cancer activity being an essential characteristic of sea cucumber active substances, we also investigated the anti-cancer potential and the underlying mechanism of SCIP in vivo and in vitro. The results indicate that SCIP inhibits the growth of MCF-7 tumor cells in zebrafish and increases the apoptosis of human breast cancer MCF-7 cells. Further mechanism studies confirm that SCIP promotes the expression of apoptosis-related proteins and thus promotes the breast cancer cells (MCF-7) apoptosis via inhibition of PI3K/AKT signal transduction pathway.

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Antiviral activity of the sea cucumber tegument extract (Pattalus mollis) on human rotavirus A (RVA)

Cited by 7 publications

References 9 publications

Advances in the development of antivirals for rotavirus infection

Advances in the development of antivirals for rotavirus infection

Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Sea Cucumber Intestinal Peptide Induces the Apoptosis of MCF-7 Cells by Inhibiting PI3K/AKT Pathway

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