Antiviral Activity of Higher Plants and Propionin on Lymphocytic Choriomeningitis Infection

Furusawa, Eiichi; Ramanathan, S.; Furusawa, Shinobu; Woo, Youn‐Hi; Cutting, Windsor C.

doi:10.3181/00379727-125-32057

Cited by 15 publications

(11 citation statements)

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“…Propionic acid bacteria have also been found to produce antiviral peptides [9,[29][30][31][32] and several bacteriocins. 60 H. Holo et al…”

Section: Introductionmentioning

confidence: 99%

Bacteriocins of propionic acid bacteria

Holo¹,

Faye²,

Brede³

et al. 2002

Lait

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-Dairy propionibacteria produce a number of inhibitory compounds like propionate, acetate and diacetyl. In addition, a number of strains produce bacteriocins. Unlike lactic acid bacteria, they often produce compounds that inhibit Gram (-) bacteria as well as yeasts and molds. These dairy propionibacteria are food-grade organisms and their bacteriocins may be of interest as food preservatives. Some of their bacteriocins have been characterized. Most are heat-stable peptides containing less than 100 amino acid residues. They are insensitive to large variations in pH, and lactic acid bacteria are often more sensitive to the bacteriocins than propionibacteria. However, at present only bacteriocins with inhibitory spectra restricted to propionibacteria have been fully sequenced. Most of the bacteriocins are produced in very low amounts when the cells are grown in liquid culture, which limits their usefulness in practical applications.

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“…Propionic acid bacteria have also been found to produce antiviral peptides [9,[29][30][31][32] and several bacteriocins. 60 H. Holo et al…”

Section: Introductionmentioning

confidence: 99%

Bacteriocins of propionic acid bacteria

Holo¹,

Faye²,

Brede³

et al. 2002

Lait

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“…However, the active agent was found to be ethanol soluble (No. 6 fraction) [6]. Experiment I also indicates that the active agent is dialyzable (No.…”

Section: Narcissus Tazetta Lmentioning

confidence: 99%

Antiviral Effects of Alkaloid Fraction of Narcissus

Ramanathan¹,

Furusawa²,

Kroposki³

et al. 1968

Chemotherapy

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“…The same fraction of narcissus (H6727-H.>0) and magnolia (H6512-HaO) as shown in the previous paper [4] were used. One tenth ml of H6727-HjO containing 2 mg of solids, and 0.1 ml of H6512-H.O containing 3 mg were the maximum non-toxic doses (MNTD) in mice.…”

Section: Methodsmentioning

confidence: 99%

“…

In previous papers [3,4], it was shown that two higher plants (Narcissus tazetta L. and Magnolia kobus DC) and an antibiotic (propionin) possess ed antiviral activity on lymphocytic choriomeningitis (LCM) infection in mice. In this paper, we report some aspects of the action mechanisms of these drugs with consideration of LCM disease as an immunologically controlled viral infection.

Materials and Methods

(1) Higher plants.

…”

mentioning

confidence: 99%