volume 47, issue 4, P769-780 2013
DOI: 10.1590/s0034-8910.2013047004529
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Abstract: ABSTRACT OBJECTIVE:To evaluate the cost-effectiveness of different drug therapies for chronic hepatitis B in adult patients. METHODS:Using a Markov model, a hypothetical cohort of 40 years for HBeAg-positive or HBeAg-negative patients was constructed. Adefovir, entecavir, tenofovir and lamivudine (with rescue therapy in cases of viral resistance) were compared for treating adult patients with chronic hepatitis B undergoing treatment for the first time, with high levels of alanine aminotransferase, no evidence…

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