Antiulcer effect of epoxy-carvone

Abstract

Epoxy-carvone is a monoterpene present in essential oils of various plants. It is a derivative of carvone, which has an epoxy group instead of the α-and β-unsaturated ketone group present in carvone. As recent studies have shown that several alcohol terpenes and compounds containing α, β-unsaturated ketone groups present antiulcer effect, the main of the present study was to evaluate the antiulcer effect of epoxy-carvone. The models of ulcers induced by ethanol and indomethacin were used in this study. Epoxy-carvone at the dose of 1 mg/kg did not present antiulcer effect against ulcer induced by ethanol, but at the doses of 10, 30 and 50 mg/kg it presented gastroprotective effect in both ulcer models. Epoxy-carvone also did not affect the gastric secretion in the pylorus ligation test. Moreover, pretreatment with indomethacin or L-nitroarginine methyl ester did not reverse the gastroprotection produced by this monoterpene. This study showed that epoxycarvone presents antiulcer effect and suggests that this effect does not involve either antisecretory activity or increase of the nitric oxide and prostaglandin synthesis.

Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

“…It is important to emphasize that is the first time that the gastroprotective activity of (1), caryophyllene oxide (3), kaurenoic acid (4), quercitrin (5) and afzelin (6) as pure compounds is showed. These results corroborate with the literature, which shows that terpenes and flavonoids exhibit protective effects on gastric ulcer and its activities are associated with cytoprotective mechanisms (Hiruma- Lima et al, 2006;Siqueira et al, 2012;Klein-Júnior et al, 2012;Santin et al, 2014). In addition, in the acute toxicity study, no signs of toxicity were observed after C. langsdorffii extract administration at the dose of 2000 mg/kg, at any time during the observation.…”

Inhibition of As(III) and Hg(II) caused aortic hypercontraction by eugenol, linalool and carvone

“…This indicates that the vasorelaxation caused by eugenol and linalool is NO-dependent whereas the vasorelaxing actions of carvone are NO-independent. The results obtained in this study are supported by reports that both eugenol and linalool induce in vivo antispasmodic effects which are endothelium released nitric oxide dependent whereas carvone acts by NO-independent mechanisms in rat isolated stomach preparations (11, 31, 32). …”

Gastroprotective Effect and Safety Assessment of <i>Zanthoxylum Zanthoxyloides</i> (Lam) Waterm Root Bark Extract

“…Tannins have also been reported to contribute immensely in gastroprotection (Dragana et al, 2009;Vasconcelos et al, 2010) while some saponins also protect the gut from ulcerogenic agents (Yoshikawa et al, 2008;Nwidu and Nwafor, 2009). A study conducted in Siqueira et al (2012), had reported the role of terpinoids in the prevention of ulcer and the healing of existing ulcers. The role of flavonoids in gastroprotection cannot be over ruled (Mota et al, 2009;Hussaini et al, 2012).…”