Antitussive and bronchodilatory effects of Lythrum salicaria polysaccharide-polyphenolic conjugate

Šutovská, Martina; Capek, Peter; Fraňová, Soňa; Pawlaczyk, Izabela; Gancarz, Roman

doi:10.1016/j.ijbiomac.2012.07.015

Cited by 26 publications

(19 citation statements)

References 29 publications

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“…Uronic acids and rhamnose contents (∼42 wt%) and the presence of galactose and arabinose residues (∼37 wt%) indicate the prevalence of pectic polysaccharide, i.e. rhamnogalacturonan and arabinogalactan in this complex, similarly as in L. salicaria conjugate, however, the content of rhamnogalacturonan was significantly lower [21]. HPLC analysis of Sc complex showed one single peak of M p (peak molecule mass) at 11.2 kDa.…”

Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 80%

“…xylose, mannose and fucose were found in lower amounts only (∼7 wt%). In Sc complex were observed relatively high protein and glucose contents in comparison with that of isolated from L. salicaria flowering parts [21]. Uronic acids and rhamnose contents (∼42 wt%) and the presence of galactose and arabinose residues (∼37 wt%) indicate the prevalence of pectic polysaccharide, i.e.…”

Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 84%

“…HPLC analysis of Sc complex showed one single peak of M p (peak molecule mass) at 11.2 kDa. Its molecule mass was significantly lower compared with that of L. salicaria conjugate (M p ∼ 3.6 and 212 kDa), although the same procedure for isolation of both isolates was used [21]. It seems that these differences in molecule masses could be due to different plant sources or organs used (flowers and flowering parts) for their isolations.…”

Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 92%

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Characterization and biological activity of Solidago canadensis complex

Šutovská

Capek

Kočmálová

et al. 2013

International Journal of Biological Macromolecules

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Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 80%

Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 84%

Section: Isolation and Chemical Composition Of S Canadensis Complexmentioning

confidence: 92%

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Characterization and biological activity of Solidago canadensis complex

Šutovská

Capek

Kočmálová

et al. 2013

International Journal of Biological Macromolecules

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“…The traditional use of arrope for dry cough would be related, in part, to the bio-adhesive property of the polysaccharides that protect the epithelial mucosa. It has been reported that water soluble polysaccharides form a bio-adhesive gel layer that protects the mucosa against physical, chemical and microbiological irritants 20 .…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Context: Ziziphus mistol (mistol) fruits and their derivate product (arrope) have been traditionally used as food and in folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorder. Objective: The objective of this study is to evaluate the antitussive and expectorant effects of Z. mistol ethanol extract (EE), aqueous extract (AE) and arrope (Ar). Materials and Methods: The antitussive activity was evaluated using two models against ammonia and citric acid induced cough in rats. The expectorant activity was evaluated by volume of phenol red secretion in rats' tracheas. The tested doses of extracts were of 250, 500 and 1000 mg/kg, (p.o.). Results: The aqueous extract and arrope showed the highest activity in all tested models. The arrope, at 1000 mg / kg, proved to be more effective with inhibitions of 79.69% and 93.75% in the number of coughs induced by ammonium liqueur and citric acid, respectively, while it was similar to codeine. Expectorant activity showed an 87.73% increase in red phenol secretion at the same dose, evidencing a higher activity compared to that of other extracts and similar to that of bromhexine. Discussion and Conclusions: This study has shown that EE, AE and Ar, have significant antitussive and expectorant effects. The present results validate their popular use to treat some pathology that affects the respiratory system. Thus, mistol fruits, mainly arrope, are proposed, as excellent phytopharmaco.

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“…99 Moreover, Elder demonstrates immune-stimulating, anticancer, 100 antiallergic, antiviral, antibacterial, bronchodilatory, antitussive activity. 101 Elder has shown significant effects towards amelioration of mechanical allodynia and hyperalgesia 24 Elder were fractioned by RP-column chromatography and RP-HPLC, and showed that the most effective compound was kaempferol. Elder has shown high efficacy against tactile allodynia after a single-administration.…”

Section: Sambucus Nigramentioning

confidence: 99%

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Raafat¹,

El-Haj²,

Shoumar³

et al. 2017

Phcog J

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Introduction:One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. Methods: A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. Results: One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients' quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. Conclusion: Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP. Consistent with this criteria NP can be classified into "defined" (all criteria present), "probable" (I and II, in addition either III or IV) or "possible" (I and II, with no confirmatory tests). 3 Moreover, risk factors and epidemiology are cornerstones in understanding NP. Risk factors and EpidemiologyThe literature survey has shown fewer studies on the NP epidemiology. A study on patients evidenced neuropathic pain in 8.2% of adult patients having significantly higher pain intensity than others in a British study. 1,4 Moreover, in a randomly selected adult population using the Douleur Neuropathique four Questions, neuropathic pain were identified in 6.9% of the examined persons in a French study. 5 NP risk factors includes: females, elderly age, minor level of education, living in a rural area worse health (compromised physical, mental and social wellbeing). [5][6][7][8][9] Pathomechanisms Pathomechanisms causing the development of NP are divided into 3 groups: first, electrophysiological properties of the cellular membrane of the first Post-amputation Pain Phantom pain was incident in amputated patients with extremity and stump pain located surrounding the post-surgical stump scar. 31 Due to the fact that strong opiods, tramadol, gabapentin, lidocaine infusions, calcitonin pregabalin or amitriptyline are recommended, evidence of effectiveness ...

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Antitussive and bronchodilatory effects of Lythrum salicaria polysaccharide-polyphenolic conjugate

Cited by 26 publications

References 29 publications

Characterization and biological activity of Solidago canadensis complex

Characterization and biological activity of Solidago canadensis complex

Untitled

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

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