Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats

Nosálóvá, G; Mokrý, Juraj; Ather, Arjumand; Khan, Majid

doi:10.2754/avb200776010027

Cited by 20 publications

(8 citation statements)

References 10 publications

(8 reference statements)

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“…Considering these points, we have developed a facile and green route to synthesize RGO using aqueous leaf extract of Paederia foetide L. (PFL) tree, which is non-toxic, rich in carotene and vitamin C and can act as both a reducing and stabilizing agent. Alcoholic extract of PFL leaf has antiinflammatory [42], anti-diarial [43] and anti-tussive [44] activity.…”

Section: Introductionmentioning

confidence: 99%

Physical and electrical characterization of reduced graphene oxide synthesized adopting green route

et al. 2016

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Graphene and its related materials are important areas of research in recent years owing to their unique properties. The wide-range industrial application of graphene-related compounds has led to the development of novel and simple methods for the synthesis of graphene. In this paper, an environmentally friendly green synthesis for the partial reduction of graphene oxide (GO) to reduced GO (RGO) in a cost-effective single-step mechanism was reported. The method completely avoids the use of toxic and environmentally harmful reducing agents commonly used in the chemical reduction of GO to obtain RGO. The reduction of GO was carried out using aqueous leaf extracts of Paederia foetide L. The prepared GO and green RGO were characterized by ultraviolet-visible, Raman and Fourier transform infra-red spectroscopic analysis which showed a clear indication of the partial removal of oxygen-containing groups from the GO and the formation of RGO. The morphology of the green RGO was characterized by transmission electron and scanning electron microscopy. Dynamic light scattering was used for zeta potential measurement and correlated with the morphology of the sheets. Electrical conductivity was also measured to check the extent of reduction of GO to RGO.

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Section: Introductionmentioning

confidence: 99%

Physical and electrical characterization of reduced graphene oxide synthesized adopting green route

et al. 2016

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“…The common name of P. foetida varies from region to region. For instance, the English name is King’s tonic or skunk vine (Nosáľová et al, 2007), whereas in China it is ji shi teng and Malaysians call this plant akar sekentut (Osman et al. 2009).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the antidiabetic potential ofPaederia foetidatwig extracts and compounds from two different locations in Malaysia

Tan

Idris

Kassim

et al. 2019

Pharmaceutical Biology

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Context: Paederia foetida L. (Rubiaceae) is an edible plant distributed in Asian countries including Malaysia. Fresh leaves have been traditionally used as a remedy for indigestion and diarrhea. Several phytochemical studies of the leaves have been documented, but there are few reports on twigs. Objective: This study investigates the enzyme inhibition of P. foetida twig extracts and compound isolated from them. In addition, in silico molecular docking of scopoletin was investigated. Materials and methods: Plants were obtained from two locations in Malaysia, Johor (PFJ) and Pahang (PFP). Hexane, chloroform and methanol extracts along with isolated compound (scopoletin) were evaluated for their enzyme inhibition activities (10,000–0.000016 µg/mL). The separation and identification of bio-active compounds were carried out using column chromatography and spectroscopic techniques, respectively. In silico molecular docking of scopoletin with receptors (α-amylase and α-glucosidase) was carried out using AutoDock 4.2. Results: The IC 50 values of α-amylase and α-glucosidase inhibition activity of PFJ chloroform extract were 9.60 and 245.6 µg/mL, respectively. PFP chloroform extract exhibited α-amylase and α-glucosidase inhibition activity (IC 50 = 14.83 and 257.2 µg/mL, respectively). The α-amylase and α-glucosidase inhibitory activity of scopoletin from both locations had IC 50 values of 0.052 and 0.057 µM, respectively. Discussion and conclusions: Separation of PFJ chloroform extract afforded scopoletin ( 1 ), stigmasterol ( 2 ) and γ-sitosterol ( 3 ) and the PFP chloroform extract yielded ( 1 ), ( 2 ), ( 3 ) and ergost-5-en-3-ol ( 4 ). Scopoletin was isolated from this species for the first time. In silico calculations gave a binding energy between scopoletin and α-amylase of −6.03 kcal/mol.

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“…Furthermore, their administration can lead to the increase of sputum viscosity, the decrease of expectoration, hypotension and constipation. All of these facts force to look for the other non-narcotic substances preventing the pathological cough [20]. One of them could be active plant polysaccharides.…”

Section: Resultsmentioning

confidence: 99%

Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system

Šutovská

Nosálóvá

Šutovský

et al. 2009

International Journal of Biological Macromolecules

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Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats

Cited by 20 publications

References 10 publications

Physical and electrical characterization of reduced graphene oxide synthesized adopting green route

Physical and electrical characterization of reduced graphene oxide synthesized adopting green route

Comparative study of the antidiabetic potential ofPaederia foetidatwig extracts and compounds from two different locations in Malaysia

Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system

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