Antitumoral effects of dovitinib in triple-negative breast cancer are synergized by calcitriol in vivo and in vitro

García-Quiroz, Janice; Cárdenas-Ochoa, Nohemí; Garcı́a-Becerra, Rocı́o; Morales-Guadarrama, Gabriela; Méndez-Pérez, Edgar A.; Santos-Cuevas, Clara; Ramírez-Nava, Gerardo; Segovia-Mendoza, Mariana; Prado-Garcı́a, Heriberto; Avila, Euclides; Larrea, Fernando; Dı́az, Lorenza

doi:10.1016/j.jsbmb.2021.105979

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…In combination with dovitinib, a multi-kinase inhibitor, calcitriol has also been demonstrated to have a synergistic antiproliferative effect in TNBC in in vitro and in vivo models. At the molecular level, the combination of these compounds induced cell death and inhibited tumor growth of BC cells to a greater extent than each compound alone [ 22 ]. Of note, at clinically achievable and safe concentrations, the combination of calcitriol with dovitinib allowed reducing the dose of the kinase inhibitor while preserving its antiproliferative effect.…”

Section: Calcitriol In Combination With Kinase Inhibitors In Bcmentioning

confidence: 99%

“…The treatment was followed for three weeks. Again, the results indicated that this administration scheme allowed antitumoral effects without hypercalcemia in the experimental animal groups that received calcitriol alone or combined with dovitinib [ 22 ].…”

Section: In Vivo Preclinical and Clinical Studies With Calcitriol-based Regimens In Bcmentioning

confidence: 99%

“…Standing out among these are the promotion of cell differentiation, anti-inflammatory effects, apoptotic actions, among others [ 15 , 16 , 17 ]. Diverse preclinical and clinical studies have focused on studying combinations of calcitriol with a variety of agents with and without chemotherapeutic action in different cancer cells, including breast cancer [ 18 , 19 , 20 , 21 , 22 ]. Unfortunately, the use of calcitriol or its analogs in cancer treatment as single agents or in combination with other antineoplastic compounds has been hindered by the failure to achieve outstanding outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update

Segovia-Mendoza

García-Quiroz

Díaz

et al. 2021

IJMS

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Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a risk factor for the development of breast cancer. Underlying mechanisms include the ability of calcitriol to induce cell differentiation, inhibit oncogenes expression, and modify different signaling pathways involved in the control of cell proliferation. In addition, calcitriol combined with different kinds of antineoplastic drugs has been demonstrated to enhance their beneficial effects in an additive or synergistic fashion. However, a recognized adjuvant regimen based on calcitriol for treating patients with breast cancer has not yet been fully established. Accordingly, in the present work, we review and discuss the preclinical and clinical studies about the combination of calcitriol with different oncological drugs, aiming to emphasize its main therapeutic benefits and opportunities for the treatment of this pathology.

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Section: Calcitriol In Combination With Kinase Inhibitors In Bcmentioning

confidence: 99%

Section: In Vivo Preclinical and Clinical Studies With Calcitriol-based Regimens In Bcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update

Segovia-Mendoza

García-Quiroz

Díaz

et al. 2021

IJMS

Self Cite

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show abstract

“…In addition to its role in calcium homeostasis, several studies showed the potential use of calcitriol in the treatment of various cancers, including breast cancer [ 18 , 19 , 20 ]. Additionally, previous studies reported the synergistic effect of calcitriol and other anticancer agents’ combination treatment in breast cancer, in vitro and in vivo [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ruxolitinib and Calcitriol Combination Treatment on Various Molecular Subtypes of Breast Cancer

Schneider

Jeon

Suh

et al. 2022

IJMS

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The anticancer effects of ruxolitinib and calcitriol against breast cancer were reported previously. However, the effect of ruxolitinib and calcitriol combination treatment on various molecular subtypes of breast cancer remains unexplored. In this study, we used MCF-7, SKBR3, and MDA-MB-468 cells to investigate the effect of ruxolitinib and calcitriol combination treatment on cell proliferation, apoptosis, cell cycle, and cell signaling markers, in vitro and in vivo. Our results revealed the synergistic anticancer effect of ruxolitinib and calcitriol combination treatment in SKBR3 and MDA-MB-468 cells, but not in MCF-7 cells in vitro, via cell proliferation inhibition, apoptosis induction, cell cycle arrest, and the alteration of cell signaling protein expression, including cell cycle-related (cyclin D1, CDK1, CDK4, p21, and p27), apoptosis-related (c-caspase and c-PARP), and cell proliferation-related (c-Myc, p-p53, and p-JAK2) proteins. Furthermore, in the MDA-MB-468 xenograft mouse model, we demonstrated the synergistic antitumor effect of ruxolitinib and calcitriol combination treatment, including the alteration of c-PARP, cyclin D1, and c-Myc expression, without significant drug toxicity. The combination exhibited a synergistic effect in HER2-enriched and triple-negative breast cancer subtypes. In conclusion, our results suggest different effects of the combination treatment of ruxolitinib and calcitriol depending on the molecular subtype of breast cancer.

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Vitamin D actions in mammary gland and breast cancer

Welsh,

Bak

2024

Feldman and Pike's Vitamin D

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Antitumoral effects of dovitinib in triple-negative breast cancer are synergized by calcitriol in vivo and in vitro

Cited by 7 publications

References 51 publications

Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update

Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update

Effects of Ruxolitinib and Calcitriol Combination Treatment on Various Molecular Subtypes of Breast Cancer

Vitamin D actions in mammary gland and breast cancer

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