Antitumor and Wound Healing Properties of Rubus ellipticus Smith.

Abstract

The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to in vitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher in vitro antioxidant activity, was taken for the evaluation of in vivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2 g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13(th) day and the 19(th) day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56 cm(3)). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.

In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation

“…These phytoconstituents express reductive activity on free radicals and may limit the appearance of mutations or even participate in DNA repair [24]. There are a few reports concerning the antitumour activity of other Rubus leaves extracts, but no data are available supporting the extracts from dewberry leaves [15, 16, 22, 25, 26]. Previous studies on in vitro models suggest that berry from Rubus species may influence colorectal cancer cell survival in concert terms proliferation and apoptosis [17].…”

Natural Compounds for Wound Healing

“…The methanol extract of Rubus ellipticus leaves showed antioxidant activity and antitumor and wound-healing properties in incision, excision, and Staphylococcus aureus-induced-infected wound models and mice with Ehrlich ascites carcinoma [119].…”

Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated fromRubus fairholmianusGard.

“…The results showed nearest value of indomethacin. Abdel-Aziz et al [61] designed a group of cyclic imides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) and evaluated its selective COX-2 inhibition. The molecular docking study showed that the CH 3 O substituents of 5b were inserted firmly to COX-2, where the O-atoms of such group underwent a H-bonding interaction with HIS 90 (2.43, 2.83Å), ARG 513 (2.89Å), and TYR 355 (3.34Å).…”

“…The literature showed that the berries (Rubus sp.) of Rosaceae family have been reported for their strong antioxidant and pharmacological properties [5][6][7][8][9] and various bioactive free radical scavenging compounds were isolated [10][11][12][13][14]. Berry fruits are characterized by a high content and wide diversity of bioactive compounds such as phenolic compounds, organic acids, tannins, anthocyanins, and flavonoids [15].…”