Antitumor and immunomodulatory activities of a water-soluble polysaccharide from Chaenomeles speciosa

Xie, Xianhong; Zou, Guolin; Li, Chenghai

doi:10.1016/j.carbpol.2015.06.046

Cited by 59 publications

(25 citation statements)

References 34 publications

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“…In recent years, the immunostimulatory effect of various polysaccharides from plants on macrophages has been reported. [41][42][43][44] However, as shown in Fig. 6(A), the active substance in SAE is unstable to heating at 100°C.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages

Ishida

Ose

Nishi

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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We herein report the immunostimulatory effect of spinach aqueous extract (SAE) on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages. SAE significantly enhanced the production of interleukin (IL)-6 and tumor necrosis factor-α by both J774.1 cells and peritoneal macrophages by enhancing the expression levels of these cytokine genes. In addition, the phagocytosis activity of J774.1 cells was facilitated by SAE. Immunoblot analysis revealed that SAE activates mitogen-activated protein kinase and nuclear factor-κB cascades. It was found that SAE activates macrophages through not only TLR4, but also other receptors. The production of IL-6 was significantly enhanced by peritoneal macrophages from SAE-administered BALB/c mice, suggesting that SAE has a potential to stimulate macrophage activity in vivo. Taken together, these data indicate that SAE would be a beneficial functional food with immunostimulatory effects on macrophages.

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Section: Discussionmentioning

confidence: 99%

Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages

Ishida

Ose

Nishi

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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“…The improvement of immunomodulatory activities in cancer by medicinal plant polysaccharides has been widely investigated. For example, a water-soluble polysaccharide from Chaenomeles speciosa increased antitumor and immunomodulatory activities in tumor-bearing mice (31). Polysaccharides from Cymbopogon citratus increased immunomodulatory activities by raising levels of TNF-α, IL-2, and IL-6 in transplanted S180 tumors (32).…”

Section: Discussionmentioning

confidence: 99%

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

et al. 2016

Oncology Reports

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Abstract. Lung cancer is the leading cause of cancer death in the world. Safflower polysaccharide (SPS) has been used for the improvement of immunomodulatory activities and treatment of cancers. However, studies on the effect of SPS on the progression of lung cancer have rarely been reported. To study the antitumor effect of SPS on human lung cancer and its potential mechanism, non-small cell lung cancer cell lines (NSCLC), A549 and YTMLC-90 were treated with SPS at various concentrations ranging from 0.04 to 2.56 mg/ml and BALB/c nude tumor-bearing mice were injected intraperitoneally with SPS at concentrations ranging from 15 to 135 mg/kg. Results showed that SPS suppressed the proliferation of A549 and YTMLC-90 cells and induced apoptosis by increasing mRNA levels of bax and caspase-3, and inhibited tumor growth in vivo. SPS induced cell cycle arrest in the G2/M phase by decreasing the expression of cdc25B and cyclin B1. Moreover, SPS decreased the expression of Akt, p-Akt and PI3K. In mice, SPS injection enhanced immunomodulatory activities by increasing levels of TNF-α and IL-6 in tumor-bearing mice. Our findings suggest that SPS suppresses tumor growth by enhancing immunomodulatory activities and blocking the PI3K/Akt pathway. This study provides new insight into the anticancer mechanism of SPS.

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“…Many studies reported the presence of the aliphatic compounds in Chaenomeles species. Nine phenols (37)(38)(39)(40)(41)(42)(43)(44)(45) were isolated from C. speciosa. Their structures of these compounds are shown in Table 5 and Figure 5.…”

Section: Phenolsmentioning

confidence: 99%

“…An average molecular weight water-soluble polysaccharide was successfully extracted from C. speciosa that is composed of glucose, rhamnose, galactose, and andarabinose. This polysaccharide is good in inhibiting the tumor growth in the mice along with improvement in delayed type hypersensitivity and higher secretion of interleukin (IL)-2, TNF-α and IFN-γ in blood serum [45]. It is further suggested that the antitumor effects of this polysaccharide is might due to the association with its potent immunostimulatory activity in vivo [45].…”

Section: Anti-tumor and Immunomodulatory Activitiesmentioning

confidence: 99%

“…This polysaccharide is good in inhibiting the tumor growth in the mice along with improvement in delayed type hypersensitivity and higher secretion of interleukin (IL)-2, TNF-α and IFN-γ in blood serum [45]. It is further suggested that the antitumor effects of this polysaccharide is might due to the association with its potent immunostimulatory activity in vivo [45]. Many of the plant based polysaccharides are less nontoxic with hardly any serious problems compared with certain synthetic compounds, hence make these polysaccharides a superior choice for modern medication [46,47].…”

Section: Anti-tumor and Immunomodulatory Activitiesmentioning

confidence: 99%

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Phytochemical and Pharmacological Properties of <em>Chaenomeles Speciosa</em>: An Edible Medicinal Chinese Mugua

Huang

Nisar

et al. 2018

Preprint

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Chaenomeles plants are adapted to diverse ecological zones particularly the temperate areas of Korea, Japan and China. In China, Chaenomeles speciosa mainly planted in Chongqing, Anhui and Hubei provinces. Most of the studies till date have been focused on the anti-inflammatory activities of C. speciosa fractions. The present study aimed to review the maximum literature reported for the presence of various phytochemicals in C. speciosa. In addition, the pharmacological properties of these chemical compounds of this plant shall also be discussed. The extracts of the various parts of the plant are rich in diversity of antioxidants, organic acids, phenolics, terpenoides and many different phytochemicals that bear strong anticancer, antioxidant, anti-viral, antibacterial properties, anti-inflammation, anti-hyperlipidemic, anti-hyperglycemic and anti-parkinson properties. C. speciosa fruits have broad scope in industry as well as in medicines. Not only the leaves and fruits of C. speciosa plant, but various other parts including roots, seeds, bark twigs, and flowers all have long history of clinical trials in curing many human ailments. However, the maximum accessible data concerning the chemical composition and their broad pharmacological properties of C. speciosa plant parts is pretty restricted that make it more appealing for indepth investigations.

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Antitumor and immunomodulatory activities of a water-soluble polysaccharide from Chaenomeles speciosa

Cited by 59 publications

References 34 publications

Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages

Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

Phytochemical and Pharmacological Properties of <em>Chaenomeles Speciosa</em>: An Edible Medicinal Chinese Mugua

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