Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice

Sauvage, Félix; Fattal, Elias; Alshaer, Walhan; Denis, Stéphanie; Brotin, Émilie; Denoyelle, Christophe; Blanc-Fournier, Cécile; Toussaint, Balthazar; Messaoudi, Samir; Alami, Mouâd; Barratt, Gillian; Vergnaud-Gauduchon, Juliette

doi:10.1016/j.canlet.2018.06.001

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…Three liposomal formulations were prepared as shown in Table 1 using the thin film hydration method as reported previously (Sauvage et al, 2018). The first formulation was the non-PEGylated one that was composed of HSPC and cholesterol in a ratio 60:40, loaded with oleuropein.…”

Section: Preparation Of Nanoliposomes (Nanophytosome)mentioning

confidence: 99%

Preparation, characterization and wound‐healing effect of PEGylated nanoliposomes loaded with oleuropein

Alquraishi,

Al‐samydai,

Al Azzam

et al. 2023

Biomedical Chromatography

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Chronic wounds have become a major concern for healthcare systems, as they have been related to diabetic foot ulcers, venous leg ulcers and pressure ulcers. Oleuropein is an active compound that is extracted from olive leaves and it has the ability to reduce injury to tissues owing to its antioxidant effect, hence improving wound healing. The poor pharmacokinetics of oleuropein have limited its use clinically. This work is aimed toward studying the impact of PEGylated and non‐PEGylated nanoliposomes loaded with oleuropein, as a carrier model, on wound‐healing activity. The thin film hydration method was used to compose PEGylated and non‐PEGylated liposomes, both loaded with oleuropein. The results indicated that each free, PEGylated and non‐PEGylated composition was within the limit of optimum nanoliposome characterization. The results showed that non‐PEGylated compositions produced higher efficiency in encapsulation (47.09 ± 10.06%) than the PEGylated ones (20.97 ± 10.52%). The PEG‐nanoliposomes loaded with oleuropein (PEG‐oleu) had mean size, charge and polydispersity index of 129.35 nm, −9.55 mV and 0.1010, respectively. The scratch assay results proved that PEGylated liposomal compositions have a more rapid wound‐healing activity than non‐PEGylated ones at different time intervals at 0, 2, 24 and 28 h.

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Section: Preparation Of Nanoliposomes (Nanophytosome)mentioning

confidence: 99%

Preparation, characterization and wound‐healing effect of PEGylated nanoliposomes loaded with oleuropein

Alquraishi,

Al‐samydai,

Al Azzam

et al. 2023

Biomedical Chromatography

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“…Although the previous systems encapsulated a N-terminal inhibitor, we developed a liposomal system in which a C-terminal inhibitor 6-BrCaQ [ 116 , 117 ] has been encapsulated as well. It has been encapsulated in liposomes and administered in vivo to mice bearing a triple negative breast cancer model.…”

Section: Will a Combination Of Both Hsp90 Inhibition And The Use Of D...mentioning

confidence: 99%

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Mathieu¹,

Messaoudi²,

Fattal³

et al. 2019

CDR

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Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local toxicity. By using Hsp90 inhibitors, some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their activities. This review will present some advantages of Hsp90 inhibitors to treat resistant tumors; especially those targeting the mitochondrial protein TRAP1. We will also focus on the targeting of the primary tumors, cancer stem cells and metastatic cells.

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“…They are classified as Hsp27, Hsp40, Hsp60, Hsp70, Hsp90, and Hsp105 based on their molecular weights [ 3 ]. The anti-apoptotic function of Hsp70 and Hsp90 had been suggested to be one of the major mechanisms of chemotherapeutic agent resistance on cancer cells [ 4 , 5 ]. Therefore, several Hsp70 and Hsp90 inhibitors are anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell

et al. 2023

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Background Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemotherapeutic agents and may be effective with a reduced dosage for tumor therapy to avoid side effects. Results Four new azaphilones, maximazaphilones I–IV (1–4), and three known compounds (5–7) have been isolated from the airborne-derived fungus Penicillium maximae. Inhibitory effects of isolated compounds against induction of Hsp105 were evaluated by the luciferase assay system using Hsp105 promoter. In this assay, 2–4, 6, and 7 significantly inhibited hsp105 promoter activity without cytotoxicity. In addition, all isolated compounds except for 5 significantly induced the death of Adriamycin (ADR)-treated HeLa cells. Interestingly, 1–4, 6, and 7 didn’t show anti-proliferative and cell death-inducing activity without ADR. Conclusion This study revealed the chemical structures of maximazaphilones I–IV (1–4) and the potency of azaphilones may be useful for cancer treatment and reducing the dose of anticancer agents. In addition, one of the mechanisms of cell death-inducing activity for 2–4, 6, and 7 was suggested to be inhibitory effects of Hsp105 expression.

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Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice

Cited by 14 publications

References 33 publications

Preparation, characterization and wound‐healing effect of PEGylated nanoliposomes loaded with oleuropein

Preparation, characterization and wound‐healing effect of PEGylated nanoliposomes loaded with oleuropein

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell

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