Antitumor activity of<i>Sansevieria roxburghiana</i>rhizome against Ehrlich ascites carcinoma in mice

Haldar, Pallab Kanti; Kar, Biswakanth; Bala, Asis; Bhattacharya, Sanjib; Mazumder, Upal Kanti

doi:10.3109/13880201003792592

Cited by 66 publications

(47 citation statements)

References 13 publications

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“…The Ehrlich ascites carcinoma (EAC) cells were initially described as a spontaneous murine mammary rapidly growing adenocarcinoma with a very aggressive behavior and can proliferate in almost all strains of mice (Haldar et al, 2010a). The Ehrlich ascitic tumor implantation induces per se a local inflammatory reaction, with increasing vascular permeability, which results in an intense edema formation, cellular migration, progressive ascitic fluid formation which is essential for tumor growth since it constitutes a direct nutritional source for tumor cells (Bala et al, 2010;Haldar et al, 2010a). From the present experiment, it is limpid that treatment with MEAC at the doses 200 and 400 mg/kg significantly reduced the tumor volume, tumor weight, tumor cell count (viable and non-viable) when compared to the tumor control group.…”

Section: Discussionmentioning

confidence: 99%

“…The ascitic fluid was drawn out from EAC tumor bearing mouse at the log phase (days 7-8 of tumor bearing) of the tumor cells. The EAC cells were maintained in vivo in Swiss albino mice by intraperitoneal transplantation of 2 Â 10 6 cells per mouse after every 10 days and it is used for both in vivo and in vitro study (Haldar et al, 2010a).…”

Section: Transplantation Of Tumor Cellsmentioning

confidence: 99%

“…Antitumor activity and antioxidant status of MEAC was assessed by observation of changes with respect to the following parameters (Haldar et al, 2010a).…”

Section: Treatment Schedule For Assessment Of In Vivo Antitumor Potenmentioning

confidence: 99%

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Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice

Dolai

Karmakar

Kumar

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Transplantation Of Tumor Cellsmentioning

confidence: 99%

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Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice

Dolai

Karmakar

Kumar

et al. 2012

Journal of Ethnopharmacology

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“…The antitumor effect of MECL was assessed by determination of tumor volume, viable and non-viable cell counts, median survival time (MST) and percentage increase in life span (% ILS). 18 …”

Section: Treatment Protocolmentioning

confidence: 99%

Antitumor potential of Citrus limetta fruit peel in Ehrlich ascites carcinoma bearing Swiss albino mice

et al. 2012

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Citrus limetta Risso (Rutaceae), commonly known as sweet lime in English and Mousambi in India, has been traditionally used for several medicinal purposes. This study explored the relationship between Citrus limetta fruit peel and its antitumor activity against Ehrlich ascites carcinoma (EAC) bearing mice. The antitumor activity of methanol extract of peel of Citrus limetta fruits (MECL) was evaluated against EAC cell line in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumor EAC cells in mice, MECL was administered at 200 and 400 mg/kg body weight i.p. daily for nine consecutive days. On the 10 th day, half of the mice were sacrificed for the estimation of tumor growth (tumor volume, viable and non-viable tumor cell counts), and hematologic parameters (red blood cells, white blood cells and hemoglobin). The rest were kept alive for assessment of survival parameters, i.e. median survival time and percentage increase in life span of EAC bearing mice. Intraperitoneal administration of MECL at the doses of 200 and 400 mg/kg for nine days to the carcinoma induced mice demonstrated a significant (P<0.001) decrease in tumor volume, viable tumor cell count, tumor weight and a significant (P<0.001) improvement in hematologica parameters and life span as compared to the EAC control mice. The present study establishes marked and dose dependant antitumor effect of C. limetta fruit peel against Ehrlich ascites carcinoma bearing Swiss mice.

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“…The reliable criterion for judging the value of any anticancer drug is the prolongation of life span of the tumor bearing animal [14]. The MST, % ILS and % S of EAC bearing mice treated with DOX/LNE were significantly longer than EAC bearing mice treated with DOX-Sol.…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of doxorubicine-loaded nanoemulsion against Ehrlich ascites carcinoma-bearing mice

Alkhatib¹,

Alkreathy²,

Balamash³

et al. 2016

Trop. J. Pharm Res

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Purpose: To evaluate the antitumor activity of doxorubicine (DOX)-loaded nanoemulsion (NE) on Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. Methods: The mice were divided into five groups (n = 20) according to the administered drug. Groups I -V were labeled as negative control (normal), positive control of the untreated EAC bearing mice (EAC control), blank nanoemulsion (BI-NE), DOX-loaded-NE (DOX/LNE) and free DOX (DOX-Sol), respectively. Cardiotoxicity was assessed by measuring changes in body and organ weight, analyzing serum enzymes and lipids, and examining histological changes in heart tissues by light microscopy. In addition, mean survival time (MST), increase in life span (ILS) and survival (S) of the mice were determined.Results: DOX/LNE group reduced levels of serum enzymes and lowered damage to heart tissues relative to DOX-Sol group. The MST of the DOX/LNE group (80 ± 0.0 days) was significantly greater than that for

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Antitumor activity ofSansevieria roxburghianarhizome against Ehrlich ascites carcinoma in mice

Cited by 66 publications

References 13 publications

Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice

Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice

Antitumor potential of Citrus limetta fruit peel in Ehrlich ascites carcinoma bearing Swiss albino mice

Antitumor activity of doxorubicine-loaded nanoemulsion against Ehrlich ascites carcinoma-bearing mice

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