2017
DOI: 10.1177/1010428317711661
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Antitumor activity of aRhodococcussp.Lut0910isolated from polluted soil

Abstract: The actinomycetes strain, lut0910, was isolated from polluted soil and identified as the Rhodococcus species with 99% similarity based on the sequence analysis of 16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro antitumor activity. The treatment of two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract caused the delay in cell propagation in a dose-dependent manner with an IC 50 of 73.39 and 33.09 µg/mL, respectiv… Show more

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Cited by 10 publications
(9 citation statements)
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“…However, there are limited studies on the antiproliferative activity of metabolites from the Rhodococcus strain. A particular Rhodococcus strain isolated from polluted soil was found to exhibit antiproliferative activity against two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cells, with an IC 50 of 73.39 and 33.09 μ g·mL −1 , respectively [73]. In this study, the antiproliferative activities of extracts from the Fictibacillus and Phaeobacter strains have been reported for the first time.…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…However, there are limited studies on the antiproliferative activity of metabolites from the Rhodococcus strain. A particular Rhodococcus strain isolated from polluted soil was found to exhibit antiproliferative activity against two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cells, with an IC 50 of 73.39 and 33.09 μ g·mL −1 , respectively [73]. In this study, the antiproliferative activities of extracts from the Fictibacillus and Phaeobacter strains have been reported for the first time.…”
Section: Discussionmentioning
confidence: 88%
“…The genus Rhodococcus has been isolated from a broad range of environments including marine animals [72]. With a broad catabolic diversity and an array of unique enzymatic activities, the genus Rhodococcus exhibits significant potential for environmental and biotechnological applications including fossil fuel biodesulfurization, bioactive steroid production, and large-scale production of acrylamide and acrylic acid [73, 74]. However, there are limited studies on the antiproliferative activity of metabolites from the Rhodococcus strain.…”
Section: Discussionmentioning
confidence: 99%
“…Ezup Column Genome DNA Extracting Kit (Sangon Biotech, Shanghai, China) was used to extract genomic DNA from high activity strains according to the manufacturer's protocol. The 16S rDNA from the extracted DNA was amplified by PCR using primer 27F (5 -AGAGTTTGATCC TGGCTCAG-3 ) and primer 338R (5 -TGCTGCCTCCCGTAGGAGT3 ) (Zhang et al, 2017a); Moreover, 18S rDNA from the extracted DNA was amplified by PCR using primer EF3 (5 -TCC TCTAAATGACCAAGTTT-3 ) and primer EF4 (5 -GGAAGGGRTGTATTTATTAG-3 ).…”
Section: Identification Based On Morphology and Dna Sequence Datamentioning
confidence: 99%
“…Another actinobacteria with discovered antitumor activity is Rhodococcus, where [77] a Rhodococcus strain was isolated from a contaminated soil. The extract exhibited cytotoxic activity against HepG2 and Hela cell line with an IC 50 of 33 and 73 μg/mL respectively.…”
Section: Antitumormentioning
confidence: 99%