Biochemical Pharmacology volume 79, issue 11, P1616-1621 2010 DOI: 10.1016/j.bcp.2010.02.006 View full text
Robert Létienne, Anne Leparq-Panissié, Yannick Calmettes, Florence Nadal-Wollbold, Michel Perez, Bruno Le Grand

Abstract: The purpose of the present work was the evaluation of the antithrombotic activity of a new PAR1 antagonist, F 16618 in arterio-venous shunt in the rat. Arterial thrombosis was induced by insertion of a silk thread (thrombogenic substrate) into an extracorporeal shunt. F 16618 was administered either by intravenous route (0.63-2.5mg/kg) or by oral route (20-80mg/kg). Oral activity of F 16618 was compared to that of aspirin (20-80mg/kg) and clopidogrel (0.63-10mg/kg). Finally, F 16618 was associated to aspirin a…

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