Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens

Mendel, Marta; Chłopecka, Magdalena; Dziekan, Natalia; Karlik, Wojciech

doi:10.1016/j.ejphar.2016.10.006

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…However, SNCE supplementation still significantly reduces this delay, possibly because of citroflavonoids that SNCE contain, namely hesperidin and naringenin. In fact, Mendel et al (2016 , 2017 ) showed that Hesperidin can possess a myocontractive action on porcine intestines in a concentration-dependant matter. Moreover, the naringenin contained in citrus product has been shown to have a laxative effect ( Yin et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Unno et al (2015) demonstrated that citroflavonoids promote the production of short-chain fatty acids in the colon, which results in pH diminution and pathogenic bacteria inhibition. Second, at least one of the citroflavonoid (Hesperidin) affects the gastrointestinal motility ( Mendel et al, 2016 ). Taken together, these results suggest that compounds of the citrus extract are active on the gut and its microbiota.…”

Section: Introductionmentioning

confidence: 99%

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Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

Cisse¹,

Benarbia²,

Burel³

et al. 2020

Translational Animal Science

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We investigated the effect of the Standardized Natural Citrus Extract (SNCE; Nor-Spice AB, Nor-Feed SAS, France) on the microbiota of the sows and on the weight gain of their piglets. Fifty sows were randomly divided into two groups: a control group (23 sows) with a standard diet and a SNCE group (27 sows) with a standard diet supplemented with 2,500 ppm of SNCE. Supplementation occurred 10 d before and 5 d after farrowing. Fecal samples from 16 sows (8 randomly selected sows of each dietary treatment) were collected for the fecal microbiota analysis 5 d after farrowing. The supplementation of SNCE increases the amount of cultivable Lactobacillus threefold in vitro. Microbial DNA was extracted from the fecal samples for sequencing of the 16S rRNA gene. The SNCE, which affected the microbiota as a discriminant analysis, was able to separate the microbial communities of the eight sows that received SNCE from the three control sows with 21 Operational Taxonomic Units (area under the ROC curve = 96%). SNCE also reduced the interval between farrowing and the first dejection of the sow and increased their feed intake (P-value < 0.05). Furthermore, feeding the sows with SNCE improved the weight gain of the piglets in the first week of life. These results show that SNCE supplementation allows to enhance zootechnical performances of peripartum’ sows, possibly due to the modulation of the microbiota transmitted to the piglets.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

Cisse¹,

Benarbia²,

Burel³

et al. 2020

Translational Animal Science

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show abstract

“…So far, many studies have approved the remarkable antispasmodic effects of the flavonoids presented in diverse plant species [102][103][104]. LN also showed an acceptable effect investigated by one study.…”

Section: Spasmolytic Propertiesmentioning

confidence: 99%

Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

et al. 2021

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Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.

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“…Disorder of smooth muscles contraction in the gastrointestinal tract or respiratory system is associated with either gastrointestinal diseases or asthma. Due to acquired resistance to conventional therapies, there is a search for new therapeutic strategies based on natural substances with potential antispasmodic activity [ 74 , 75 ]. Zoofishan et al [ 12 ] evaluated antispasmodic activity of ingredients of Morus nigra .…”

Section: Biological Effects Of Morusin and Its Derivativesmentioning

confidence: 99%

The Pro-Health Benefits of Morusin Administration—An Update Review

Panek-Krzyśko

Stompor-Gorący

2021

Nutrients

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Prenylflavonoids are widespread in nature. Plants are valuable sources of natural polyphenolic compounds with isoprenyl groups, which include flavones, flavanones, chalcones and aurones. They can be found in flowers, bark and stems. One of the most important compounds found in the bark of white mulberry (Morus alba) is morusin, a prenylated flavone with interesting pro-health properties. The research carried out so far revealed that morusin has antioxidant, antitumor, anti-inflammatory and anti-allergic activity. Moreover, its neuroprotective and antihyperglycemic properties have also been confirmed. Morusin suppresses the growth of different types of tumors, including breast cancer, glioblastoma, pancreatic cancer, hepatocarcinoma, prostate cancer, and gastric cancer. It also inhibits the inflammatory response by suppressing COX activity and iNOS expression. Moreover, an antimicrobial effect against Gram-positive bacteria was observed after treatment with morusin. The objective of this review is to summarize the current knowledge about the positive effects of morusin on human health in order to facilitate future study on the development of plant polyphenolic drugs and nutraceutics in the group of prenylflavones.

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Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens

Cited by 18 publications

References 30 publications

Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

The Pro-Health Benefits of Morusin Administration—An Update Review

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