Antiseptics for burns

Norman, Gill; Christie, Janice; Liu, Zhenmi; Westby, Maggie J; Jefferies, Jayne M; Hudson, Tom; Edwards, Jacky; Mohapatra, Devi Prasad; Hassan, Ibrahim A.; Dumville, Jo C

doi:10.1002/14651858.cd011821.pub2

Cited by 70 publications

(68 citation statements)

References 99 publications

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“…Numerous randomized controlled clinical studies and case reports have been conducted in order to prove its wound-healing efficacy. A meta-analysis investigating the efficacy of honey in different types of wounds indicated that the relative effect of honey on wounds was unclear because the trials performed so far have been small, clinically heterogeneous, short, and highly biased [1][2][3][4][5]. However, some systematic reviews and meta-analyses have indicated that honey dressings are superior in the treatment of diabetic foot ulcers or burns when compared to conventional dressings [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria

et al. 2020

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Multifactorial antibacterial action is an important feature of honey; however, its bactericidal efficacy against biofilm-embedded bacteria is limited. The aim of this study was to investigate the impact of vitamin C (Vit C) on the antibacterial activity of natural honeys against planktonic as well as biofilm-embedded bacterial pathogens. The antibacterial activity of four honey samples supplemented with Vit C was expressed as the minimum inhibitory concentration (MIC). At sub-MICs, Vit C significantly increased the antibacterial activity of the tested honeys against Pseudomonas aeruginosa in planktonic cultures. However, after supplementation, honeydew honey, the most active honey, was ineffective against Staphylococcus aureus. On the other hand, when 100% honeydew honey was supplemented with Vit C (100 mg/g of honey) in a multispecies wound biofilm model, complete eradication of almost all bacterial isolates, including S. aureus, was observed. Furthermore, a mixture of honey and Vit C was partially effective against Enterococcus faecalis, whereas honey alone exhibited no antibacterial activity against this bacterium. Vit C counteracted hydrogen peroxide in honey solution and, thus, eliminated the major antibacterial compound present in honey. It is likely that a combination of honey with Vit C may trigger the intracellular production of reactive oxygen species in bacterial cells, but the exact cellular mechanisms warrant further investigations.

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Section: Introductionmentioning

confidence: 99%

Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria

et al. 2020

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“…Aloe extracts are used in a wide variety of medicinal and cosmetic products marketed for skin healing, and numerous patents cover the use of acetylated mannans from Aloe vera due to their supposed immunomodulatory effects (45,46). However, two recent Cochrane reviews found that published studies on the wound healing and antiseptic properties of this plant were generally of low quality and that the results of human trials that have been published returned variable results, spanning from help and harm to the patients (47,48). The available literature on the biological composition and activity of mastic was even less clear.…”

Section: Results and Discussion Network Analysis Of Remedies For Skinmentioning

confidence: 99%

“…while the most potent medical-grade honey (manuka honey) also contains highly active compounds from the plant from which it is made, a range of European honeys have been shown to have measurable antimicrobial effects in vitro (74)(75)(76)(77). Cochrane reviews found moderate to good evidence that honey reduces healing times for burns and surgical wounds (48,78) and weak evidence that honey helps to prevent mouth ulcers in cancer patients (79), and another Cochrane review suggested that honey may be better than no treatment or placebo in relieving childhood cough (80).…”

Section: Results and Discussion Network Analysis Of Remedies For Skinmentioning

confidence: 99%

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

Connelly¹,

Genio

Harrison

2020

mBio

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The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of searching and interpreting historical medical texts. Here, we demonstrate the potential power of turning medieval medical texts into contextualized electronic databases amenable to exploration by the use of an algorithm. We used established methodologies from network science to reveal patterns in ingredient selection and usage in a key text, the 15th-century Lylye of Medicynes, focusing on remedies to treat symptoms of microbial infection. In providing a worked example of data-driven textual analysis, we demonstrate the potential of this approach to encourage interdisciplinary collaboration and to shine a new light on the ethnopharmacology of historical medical texts. IMPORTANCE We used established methodologies from network science to identify patterns in medicinal ingredient combinations in a key medieval text, the 15thcentury Lylye of Medicynes, focusing on recipes for topical treatments for symptoms of microbial infection. We conducted experiments screening the antimicrobial activity of selected ingredients. These experiments revealed interesting examples of ingredients that potentiated or interfered with each other's activity and that would be useful bases for future, more detailed experiments. Our results highlight (i) the potential to use methodologies from network science to analyze medieval data sets and detect patterns of ingredient combination, (ii) the potential of interdisciplinary collaboration to reveal different aspects of the ethnopharmacology of historical medical texts, and (iii) the potential development of novel therapeutics inspired by premodern remedies in a time of increased need for new antibiotics.

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“…The effect of the treatment on wound healing was studied macroscopically and using histology. In terms of reduction of wound bacterial counts the NPWT was compared to topical silver sulfadiazine cream which is commonly used antimicrobial in burn care …”

Section: Introductionmentioning

confidence: 99%

Novel negative pressure wound therapy device without foam or gauze is effective at −50 mmHg

Nuutila

Yang

Broomhead

et al. 2018

Wound Repair Regeneration

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Negative pressure wound therapy (NPWT) promotes healing in acute or chronic wounds. Conventional NPWT devices consist of a filler (such as foam or gauze) that covers the wound and of a permeable membrane and tubing that connects the space under the membrane to a suction pump. The permeable membrane increases airflow and thus increases the required pump capacity that can cause patient discomfort or even ischemia in wounds with compromised vascularity. In addition, foam or gauze may fragment and become colonized with bacteria over time. To mitigate these, negative aspects, we have developed a new impermeable single layer component membrane dressing to deliver NPWT that does not need a foam or gauze to function. Therefore, the purpose of this study was to introduce this novel NPWT system (platform wound device, PWD) and evaluate its usability and effectiveness in the treatment of porcine full-thickness burns. A total of 48 burn wounds were created across four Yorkshire pigs on the dorsum. Wounds were created on day 0 and continuous NPWT with −50 mmHg and − 80 mmHg was initiated immediately. Subsequently, the burns were debrided on day 3 and animals were euthanized on day 7. The efficacy of the PWD on wound healing and reduction of bacterial burden was measured and compared to wounds that did not receive NPWT. The results showed that PWD promoted wound healing by outperforming the wounds that did not receive NPWT and that PWD was efficient at reducing bacteria from the burn eschar and from the wound bed. In conclusion, this study demonstrated that PWD promoted wound healing with a negative pressure as low as −50 mmHg, which likely benefits healing and avoids potential safety issues.

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Antiseptics for burns

Cited by 70 publications

References 99 publications

Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria

Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

Novel negative pressure wound therapy device without foam or gauze is effective at −50 mmHg

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