Antireproductive effect of calcium channel blockers on male rats

Morakinyo, Ayodele Olufemi; Iranloye, Bolanle; Adegoke, Olufeyisipe

doi:10.1007/s12522-009-0018-9

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…Furthermore, intracellular sodium and calcium levels are critically important for sperm motility, viability, and acrosome reaction. [50][51][52][53][54] It is known that ZNS's mechanisms of action were considered to be its inhibitory effects on voltagegated sodium channel and voltage-sensitive calcium channels. 55,56 Therefore, it could be concluded that the decrease of sperm motility with ZNS administration may be associated with the mechanism of action of this drug including blocking of sodium channels and reducing calcium channel currents.…”

Section: Discussionmentioning

confidence: 99%

Reproductive toxic effects and possible mechanisms of zonisamide in male rats

et al. 2019

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Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. Therefore, we aimed to assess the effects of ZNS on male reproductive system by oral administration to rats in 25, 50, and 100 mg/kg doses for 28 days. After the exposure period, sperm concentration, motility, morphology, and DNA damage, as biomarkers of reproductive toxic effects, were determined, and histopathological examination of testis was performed. In addition, levels of the hormones that play a role in the regulation of reproductive functions, such as follicle-stimulating hormone, luteinizing hormone (LH), and testosterone were measured and the levels of oxidative stress biomarkers that take part in the reproductive pathologies such as catalase, superoxide dismutase, glutathione, and malondialdehyde, were determined. Reproductive toxic effects related to ZNS administration were shown by the significant decrease of sperm concentration and normal sperm morphology in ZNS groups. Additionally, pathological findings were observed in the testicular tissues of ZNS-administered groups dose dependently. In addition, serum LH and testosterone levels were significantly decreased in the ZNS groups. Decreased catalase activities and increased malondialdehyde levels in ZNS groups were evaluated as oxidative stress findings in the testis tissue. It could be expressed that ZNS administration induced dose-dependent reproductive toxic effects in rats, and pathological findings associated with the reproductive system could be the result of that hormonal changes and testicular oxidative stress, which in turn might be considered as possible mechanisms of male reproductive toxicity.

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Section: Discussionmentioning

confidence: 99%

Reproductive toxic effects and possible mechanisms of zonisamide in male rats

et al. 2019

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“…Iranloye et al suggested that oral daily administration of 0.57 mg/kg Nif for 30 days causes reversible deleterious effects on sperm function which is not mediated by a change in testosterone secretion (14). Morakinyo et al equally reported that administration of Nif, verapamil, and diltiazem for 30 days appear to have a reversible anti-fertility effect on male rats which does not occur through inhibition of the pituitary-gonadal axis (15).…”

Section: Discussionmentioning

confidence: 99%

Early effects of concurrent administration of artesunate-amodiaquine and nifedipine on sperm parameters and sex hormones in guinea pigs: An experimental study

Aprioku

2018

IJRM

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Background: Many antimalarial agents and calcium channel blockers have been demonstrated to alter male reproductive activity. Increasing prevalence of hypertension, therefore, increases concern of male infertility, and concurrent administration of antihypertensive and antimalarial agents in malaria-prone areas. Objective: The study evaluates the reproductive effect of co-administration of artesunate (Ats)-amodiaquine (Amod) and nifedipine (Nif) in male guinea pigs. Materials and Methods: In this experimental study, 24 adult male pigs were divided into four groups (n=6/ each) as one control (given distilled water) and 3 intervention groups (given standard daily dose equivalents of Ats-Amod, Nif or combination of both drugs) for 14 days. Serum levels of testosterone, folliclestimulating hormone and luteinizing hormone were measured using enzyme-linked immunosorbent assay. Testicular weight was measured and the relative weight (organ-to-body weight ratio) was obtained. Sperm count, motility, and morphology were equally analyzed. Results: Nif treatment produced no significant effect on the hormone levels (p=0.058) and sperm parameters (p=0.0568) that were measured, whereas Ats-Amod and Ats-Amod+Nif decreased testosterone level (p=0.0482), sperm count and motility (p<0.0001), but failed to cause an alteration in follicle-stimulating hormone, luteinizing hormone and sperm morphology. Percentage of motility reduction by Ats-Amod+Nif was greater (p=0.025) compared to Ats-Amod effect. Relative testicular weight was decreased (p=0.046) by Ats-Amod and Ats-Amod+Nif, but unaffected by Nif. Conclusion: The result suggests that short-term administration of standard daily dose equivalent of Nif does not alter hormone levels and sperm indices, while Ats-Amod alone or in combination with Nif decreases testosterone, sperm count, and motility. The combination also results in synergistic inhibition of sperm motility.

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“…Alpha‐adrenergic blockers are known to cause retrograde ejaculation and impair sperm concentration and motility . Calcium channel blockers impair sperm motility in vitro , the sperm fertilization process, and overall male fertility . Discontinuation of calcium channel blockers and a switch to alternative antihypertensive drugs should be considered.…”

Section: Discussionmentioning

confidence: 99%