Antipyrine clearance in comparison to conventional liver function tests in hepatitis C virus patients

Mahmoud, Madiha R.; Abdel-Kader, Rania; Hassanein, M. K.; Saleh, S. A.; Botros, Sanaa S.

doi:10.1016/j.ejphar.2007.04.061

Cited by 37 publications

(13 citation statements)

References 29 publications

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“…In fact, NTCP reportedly has an important role in hepatic uptake of ursodeoxycholic acid (Mita et al, 2006). Recent report indicated INR of prothrombin time negatively correlated with antipyrine clearance, informative indices for hepatic impairment in hepatitis C patients (Mahmoud et al, 2007). The results were quite consistent with our results because antipyrine was shown to be a substrate for CYP1A2 and CYP3A4 (Rendic, 2002).…”

Section: Discussionsupporting

confidence: 83%

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Nakai

Tanaka²,

Hanada³

et al. 2008

Drug Metab Dispos

112

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ABSTRACT:Patients with chronic hepatitis C viral infection underwent liver biopsies and laboratory studies for evaluation and to determine subsequent treatment. Changes in status of drug metabolism and disposition may vary with chronic hepatitis C stage and should be assessed. Total RNA was extracted from liver biopsy specimens (n ‫؍‬ 63) and reverse transcribed to yield cDNA. Relative mRNA levels of drug-metabolizing enzymes, transporters, nuclear receptors, and proinflammatory cytokines were analyzed with normalization to glyceraldehyde 3-phosphate dehydrogenase expression. mRNAs encoding cytochromes P450 1A2, 2E1, and 3A4, and drug transporters, Na ؉ -taurocholate-cotransporting polypeptide, organic anion-transporting peptide-C, and organic cation transporter 1 showed remarkable decreases, and tumor necrosis factor-␣ showed an increase according to fibrosis stage progression. HepG2 cells and primary hepatocytes of two human individuals were treated with interleukin 1␤, interleukin 6, or tumor necrosis factor-␣. CYP1A2 and Na ؉ -taurocholate-cotransporting polypeptide mRNA levels significantly decreased in HepG2 cells with interleukin 1␤ and interleukin 6 treatments. CYP2E1 and organic cation transporter 1 mRNA levels significantly decreased with tumor necrosis factor-␣ treatment only in HepG2. These results suggested that down-regulation of CYP1A2, 2E1, and 3A4, and drug transporters, Na ؉ -taurocholate-cotransporting polypeptide, organic anion-transporting peptide-C, and organic cation transporter 1, manifested in livers of patients with chronic hepatitis C viral infection, was associated, at least in part, with the elevated production of proinflammatory cytokines, including tumor necrosis factor-␣.Infection and inflammation generally cause a decrease in hepatic capacity for drug metabolism and disposition. Using lipopolysaccharide models of hepatic inflammation, a number of investigators have demonstrated decreases in the expression of various drug-metabolizing enzymes (Iber et al., 1999;Renton, 2004). Bacterial and viral infections are associated with the induction of various cytokines, including interleukins (ILs) 1␤ and 6, tumor necrosis factor (TNF)-␣, and interferon-␥, which decrease the level of hepatic drug-metabolizing enzymes (Iber et al., 1999;Renton, 2004). Hepatitis C virus (HCV) infection was reported to cause changes in levels of drugmetabolizing enzymes cytochrome P450 2E1 (Gochee et al., 2003), an oxidative stress-related enzyme, and glutathione peroxidase (Levent et al., 2006); and nuclear receptors, including peroxisome proliferator-

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Section: Discussionsupporting

confidence: 83%

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Nakai

Tanaka²,

Hanada³

et al. 2008

Drug Metab Dispos

112

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“…Unclear classification of hepatic impairment was considered on a case-by-case basis. In particular, when antipyrine clearance was reported, but not the Child-Pugh score, patients were classified as A, B, or C when antipyrine clearance was approximately 75, 50, and 30 % of the control value [18]. If biological results did not allow the Child-Pugh score to be determined, the data were rejected.…”

Section: Article Selectionmentioning

confidence: 99%

A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child–Pugh Classification

et al. 2015

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“…In pharmacology, APDs have been widely used as an effective antitumor, [1] antimicrobial, [2 -6] antiviral, [7] analgesic, [8] anti-inflammatory [9] and anticancer drugs. [10] In coordination chemistry, APDs were used as important ligands in synthesizing complexes with metal ions.…”

Section: Introductionmentioning

confidence: 99%

VUV photon‐induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

et al. 2010

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Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time-of-flight mass spectrometer (EI-TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway.

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Antipyrine clearance in comparison to conventional liver function tests in hepatitis C virus patients

Cited by 37 publications

References 29 publications

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child–Pugh Classification

VUV photon‐induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

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Antipyrine clearance in comparison to conventional liver function tests in hepatitis C virus patients

Cited by 37 publications

References 29 publications

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child–Pugh Classification

VUV photon‐induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

Contact Info

Product

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Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients