Antipsychotic drugs for non-affective psychosis during pregnancy and postpartum

Psychiatric illness and adverse pregnancy outcome

“…Our study demonstrated that pregnant psychiatric patients have high‐risk characteristics such as advanced maternal age, diabetes, and hypertensive disorders, which have not been identified in other cohort studies [3,9]. Since this high‐risk status was shown to influence pregnancy outcome, as demonstrated, while adjusting for concomitant psychiatric illness, we controlled for these variables in the analysis (Table 4).…”

Psychiatric illness and adverse pregnancy outcome

“…Our study demonstrated that pregnant psychiatric patients have high‐risk characteristics such as advanced maternal age, diabetes, and hypertensive disorders, which have not been identified in other cohort studies [3,9]. Since this high‐risk status was shown to influence pregnancy outcome, as demonstrated, while adjusting for concomitant psychiatric illness, we controlled for these variables in the analysis (Table 4).…”

Schizophrenia and Sex Hormones: What Is the Link?

“…Psychotic denial of pregnancy is a symptom that poses especially high risks for poor outcomes if not addressed. Up to now, little research has been done into interventions for psychotic disorders in pregnancy and in particular, few studies have been done into use of antipsychotic medication ( 46 , 47 ). Research on the safety of medication during pregnancy and breastfeeding is limited.…”

“…During the postpartum period, mental health home visits should be provided. Parenting support is critical” ( 46 , 47 ).…”

A Systematized Review of Atypical Antipsychotics in Pregnant Women

“…30 Strength of evidence on this topic is limited by methodological shortcomings (the retrospective, observational designs and the difficulty in controlling for confounding variables such as psychiatric diagnosis, maternal age, use of alcohol and other substances or medication, smoking, gravidity history, previous pregnancy loss, genetic history, and dose and timing of drug exposure); nonetheless, schizophrenia and related altered behaviors may be considered risk factors for congenital malformations. 51,60,94,95 To date, although the evidence either against or for the potential risk of teratogenesis with SGA use is limited, 4,96 SGAs, as a class and singularly, are not strongly associated with increased recurring defects in fetuses. This conclusion comes from studies that examined antipsychotic exposure during pregnancy irrespective of the psychiatric diagnosis for which mothers were prescribed SGAs (not only bipolar disorder or schizophrenia but also major depression or anxiety disorders); thus, it is not limited to mothers with bipolar disorder or schizophrenia exposed during the first trimester of pregnancy to antipsychotics.…”

Psychiatric illness and adverse pregnancy outcome

“…Our study demonstrated that pregnant psychiatric patients have high‐risk characteristics such as advanced maternal age, diabetes, and hypertensive disorders, which have not been identified in other cohort studies [3,9]. Since this high‐risk status was shown to influence pregnancy outcome, as demonstrated, while adjusting for concomitant psychiatric illness, we controlled for these variables in the analysis (Table 4).…”

Schizophrenia and Sex Hormones: What Is the Link?

“…Psychotic denial of pregnancy is a symptom that poses especially high risks for poor outcomes if not addressed. Up to now, little research has been done into interventions for psychotic disorders in pregnancy and in particular, few studies have been done into use of antipsychotic medication ( 46 , 47 ). Research on the safety of medication during pregnancy and breastfeeding is limited.…”

“…During the postpartum period, mental health home visits should be provided. Parenting support is critical” ( 46 , 47 ).…”

A Systematized Review of Atypical Antipsychotics in Pregnant Women

“…30 Strength of evidence on this topic is limited by methodological shortcomings (the retrospective, observational designs and the difficulty in controlling for confounding variables such as psychiatric diagnosis, maternal age, use of alcohol and other substances or medication, smoking, gravidity history, previous pregnancy loss, genetic history, and dose and timing of drug exposure); nonetheless, schizophrenia and related altered behaviors may be considered risk factors for congenital malformations. 51,60,94,95 To date, although the evidence either against or for the potential risk of teratogenesis with SGA use is limited, 4,96 SGAs, as a class and singularly, are not strongly associated with increased recurring defects in fetuses. This conclusion comes from studies that examined antipsychotic exposure during pregnancy irrespective of the psychiatric diagnosis for which mothers were prescribed SGAs (not only bipolar disorder or schizophrenia but also major depression or anxiety disorders); thus, it is not limited to mothers with bipolar disorder or schizophrenia exposed during the first trimester of pregnancy to antipsychotics.…”

Psychiatric illness and adverse pregnancy outcome

“…Our study demonstrated that pregnant psychiatric patients have high‐risk characteristics such as advanced maternal age, diabetes, and hypertensive disorders, which have not been identified in other cohort studies [3,9]. Since this high‐risk status was shown to influence pregnancy outcome, as demonstrated, while adjusting for concomitant psychiatric illness, we controlled for these variables in the analysis (Table 4).…”

Schizophrenia and Sex Hormones: What Is the Link?

“…Psychotic denial of pregnancy is a symptom that poses especially high risks for poor outcomes if not addressed. Up to now, little research has been done into interventions for psychotic disorders in pregnancy and in particular, few studies have been done into use of antipsychotic medication ( 46 , 47 ). Research on the safety of medication during pregnancy and breastfeeding is limited.…”

“…During the postpartum period, mental health home visits should be provided. Parenting support is critical” ( 46 , 47 ).…”

A Systematized Review of Atypical Antipsychotics in Pregnant Women

“…30 Strength of evidence on this topic is limited by methodological shortcomings (the retrospective, observational designs and the difficulty in controlling for confounding variables such as psychiatric diagnosis, maternal age, use of alcohol and other substances or medication, smoking, gravidity history, previous pregnancy loss, genetic history, and dose and timing of drug exposure); nonetheless, schizophrenia and related altered behaviors may be considered risk factors for congenital malformations. 51,60,94,95 To date, although the evidence either against or for the potential risk of teratogenesis with SGA use is limited, 4,96 SGAs, as a class and singularly, are not strongly associated with increased recurring defects in fetuses. This conclusion comes from studies that examined antipsychotic exposure during pregnancy irrespective of the psychiatric diagnosis for which mothers were prescribed SGAs (not only bipolar disorder or schizophrenia but also major depression or anxiety disorders); thus, it is not limited to mothers with bipolar disorder or schizophrenia exposed during the first trimester of pregnancy to antipsychotics.…”