Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang.

Dai, Yue; But, Paul Pui‐Hay; Chan, Yiu-Pong; Matsuda, Hideaki; Kubo, Michinori

doi:10.1248/bpb.25.1175

Cited by 45 publications

(38 citation statements)

References 12 publications

(12 reference statements)

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“…China, 2010). In comparison with individual herbs, compound formulae always exhibit greater efficiency (Dai et al, 2002;Chen et al, 2006;Liu et al, 2010a) and lower toxicity (Wang et al, 1997). The therapeutic potencies of herbs are found additive, or even synergistic, when used as combination (Wang et al, 1995;Gao et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing

Lau

Lai

Liu

et al. 2012

Journal of Ethnopharmacology

116

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Section: Discussionmentioning

confidence: 99%

Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing

Lau

Lai

Liu

et al. 2012

Journal of Ethnopharmacology

116

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“…30,31) Also, it was reported that Lycii Fructus and Corni fructus, components of YMJd presented a strong anti-oxidative effects. 32,33) In addition to such anti-oxidant effects from some components of YMJd, it was found that Lycii Fructus, 34) Rehmannia radix, 35) Discoreae radix, 36) Corni fructus, 37) and Mountain cortex radicis, 38) components of YMJd showed anti-inflammatory effects. Thus, such anti-oxidative and anti-inflammatory effects from those components in YMJd may have been responsible for the protection against ibotenic acid-induced cell damage and cognitive deficits shown in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Yukmijihwang-tang Derivatives (YMJd) on Ibotenic Acid-Induced Amnesia in the Rat

Kang

Kim

Cho

et al. 2006

Biological & Pharmaceutical Bulletin

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The consistent findings in Alzheimer's disease (AD) patients are impairment in cognitive performances such as attention, learning and memory, and change of cholinergic markers, including levels of acetylcholine (ACh) and choline acetyltransferase (ChAT). [1][2][3] Since cholinergic deficits are found to be associated with cognitive decline or dementia, increase of the central cholinergic system by selective inhibition of cholinesterase is one of the more promising current therapeutic tools for treating AD.4) Cholinergic neurons originating in the nucleus basalis of Meynert (NBM) and the medial septum (MS) project to areas such as the cortex and hippocampus, where play the role of ACh in cognition. 5,6) Lesioning these pathways in rodents decreases ACh release and produces an impairment of memory-related task performance.7) The observations that impairment can be reversed by cholinergic agonists suggest that the cholinergic system is damaged in AD and that drugs which induce cholinergic activity may treat AD. 8) For the testing of putative, cognitionenhancing agents, the establishment and standardization of animal cognitive deficit models are required. Lesion of the MS in animals has been widely approved as an animal model of memory loss.9,10) Cognitive dysfunctions after lesioning the MS are mainly considered to be due to deafferentiation of the hippocampus, which plays a major role in learning and memory. Coordinated action of acetylcholine and glutamate is important for the production of memory.11,12) ACh facilitates glutamate activity by coordinating the states of acquisition and recall in the cortex and hippocampus 13) and the activation of N-methyl-D-aspartate (NMDA) receptors is a prerequisite for the stimulation of long-term potentiation (LTP) in the septohippocampal cholinergic system, which is involved in the memory performance of rats in some learning tasks that depend on hippocampal functions. 14) Ibotenic acid stimulates neuronal necrosis by a hyperstimulation of the NMDA glutamate receptors leading to calcium overload. Its excitotoxic properties are confined to somata of neurons and therefore axons and blood vessels that course through the target areas remain intact.15) Injections of ibotenic acid into the MS in rats result in a significant deficit in the Morris water maze, which has been designed to measure spatial learning and memory, 16) and provide a more advanced stage of the neurodegeneration as an animal model of AD.7) Herbal medicines, such as Ginko biloba, Ginseng, or Melisa officinalis, have been commonly used as memory or cognition enhancers. The effects of these enhancers have been demonstrated scientifically.17,18) Yukmijihwang-tang (YMJ or Luweidihuang-wang) is another memory or cognition enhancer. YMJ is composed of 6 herbal medicines, including steamed Rehmannia radix, Discoreae radix, Corni fructus, Hoelen, Mountain cortex radicis, and Alismatis radix. YMJ has long been applied in the treatment of diabetes mellitus and neurosis. Ancient Chinese herbal textbooks also refer to YMJ as ...

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“…A digital vernier caliper (Model 2061, Mututoyo Digimatic Caliper, Japan) used for measuring paw thickness (mm) of rats. 15,16) Edema (∆T) was calculated as follows…”

Section: Introductionmentioning

confidence: 99%

“…The thickness (mm) of the paw was measured immediately and at 1, 2, 3, and 4 hr intervals after the injection of the carrageenan. 15,[17][18][19][20] Histamine and Serotonin Induced Edema in Rats ---Edema in rats was induced by injecting 0.1 ml of 0.1% w/v histamine or 0.2% w/v serotonin in subplantar region of the right hind paw. The thickness (mm) of the paw was measured immediately and at 1, 2, 3, and 4 hr intervals after the administration of the histamine or serotonin.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract

Mani

Gunnam

Parle

2006

JOURNAL OF HEALTH SCIENCE

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The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory and analgesic activity at the doses [per oral (p.o.)] of 100, 200 and 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine-and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats. The acetic acid-induced writhing response and formalin-induced paw licking time in the early and late phases of mice were used to assess analgesic activity. The higher doses of DCE (200 and 400 mg/kg, p.o.) were inhibiting carrageenan, histamine and serotonin-induced paw edema as well as formaldehyde-induced arthritis successfully. In addition, DCE (200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by an subplantar injection of formalin in mice.

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Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang.

Cited by 45 publications

References 12 publications

Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing

Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing

Effects of Yukmijihwang-tang Derivatives (YMJd) on Ibotenic Acid-Induced Amnesia in the Rat

Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract

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